Epas1 - endothelial PAS domain protein 1 Gene

Also Known as HLF; HRF; MOP2; HIF2A; bHLHe73; HIF-2alpha

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13819

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein heterodimerization activity. Involved in mRNA transcription by RNA polymerase II; myoblast fate commitment; and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including animal organ development; regulation of transcription by RNA polymerase II; and surfactant homeostasis. Located in cytoplasm and nuclear speck. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and respiratory system. Used to study newborn respiratory distress syndrome. Human ortholog(s) of this gene implicated in familial erythrocytosis 4; lung non-small cell carcinoma; polycythemia; and pulmonary hypertension. Orthologous to human EPAS1 (endothelial PAS domain protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Epas1 Products (1)

mRNA Protein Name
NM_010137.3 NP_034267.3 endothelial PAS domain-containing protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
17404621 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
21856340 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
12464608 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IGI
IGI: Inferred from genetic interaction
9113979 MGI
enables cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
12464608 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9113979 MGI
enables protein heterodimerization activity IDA
IDA: Inferred from direct assay
26245371 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
26245371 MGI
enables transcription factor binding IPI
IPI: Inferred from physical interaction
12464608 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within angiogenesis IMP
IMP: Inferred from mutant phenotype
12053176 MGI
acts upstream of or within blood vessel remodeling IMP
IMP: Inferred from mutant phenotype
10880563 MGI
acts upstream of or within cell differentiation IGI
IGI: Inferred from genetic interaction
16287860 MGI
acts upstream of or within embryonic placenta development IGI
IGI: Inferred from genetic interaction
16287860 MGI
acts upstream of or within epithelial cell maturation IMP
IMP: Inferred from mutant phenotype
12053176 MGI
acts upstream of or within erythrocyte differentiation IMP
IMP: Inferred from mutant phenotype
17284606 MGI
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
25414188 MGI
involved in gene expression IMP
IMP: Inferred from mutant phenotype
18635823 MGI
acts upstream of or within hemopoiesis IMP
IMP: Inferred from mutant phenotype
12750163 MGI
acts upstream of or within lung development IMP
IMP: Inferred from mutant phenotype
12053176 MGI
involved in mRNA transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
18635823 MGI
acts upstream of or within mitochondrion organization IMP
IMP: Inferred from mutant phenotype
14608355 MGI
acts upstream of or within multicellular organismal-level iron ion homeostasis IGI
IGI: Inferred from genetic interaction
22128145 MGI
involved in myoblast fate commitment IMP
IMP: Inferred from mutant phenotype
21106753 MGI
acts upstream of or within norepinephrine metabolic process IMP
IMP: Inferred from mutant phenotype
9808618 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
26572826 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12464608 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
9113979 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
17404621 MGI
acts upstream of or within regulation of heart rate IMP
IMP: Inferred from mutant phenotype
9808618 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
14608355 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
12832481 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
17284606 MGI
acts upstream of or within response to hypoxia IMP
IMP: Inferred from mutant phenotype
15626745 MGI
acts upstream of or within response to oxidative stress IGI
IGI: Inferred from genetic interaction
17322295 MGI
acts upstream of or within response to oxidative stress IMP
IMP: Inferred from mutant phenotype
14608355 MGI
acts upstream of or within surfactant homeostasis IMP
IMP: Inferred from mutant phenotype
12053176 MGI
acts upstream of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
17404621 MGI
acts upstream of or within visual perception IMP
IMP: Inferred from mutant phenotype
15728559 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12832481 MGI
located in nuclear speck IDA
IDA: Inferred from direct assay
21546903 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12464608 MGI
part of transcription regulator complex IDA
IDA: Inferred from direct assay
12464608 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

endothelial PAS domain-containing protein 1

  • EPAS-1

  • HIF-1-alpha-like factor

  • HIF-2-alpha

  • HIF-related factor

  • HIF1 alpha-like factor

  • HIF1alpha-like factor

  • HIF2-alpha

  • HLF (HIF1alpha-like factor)

  • Hif like protein

  • hypoxia inducible transcription factor 2alpha

  • hypoxia-inducible factor 2-alpha

  • mH

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-147426 Zifcasiran Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04409 EPAS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-147426A Zifcasiran sodium Inhibitor / Unkown
HY-B0660S1 Eicosapentaenoic acid 1,2,3,4,5-13C5 Activator / Unkown
HY-RS18998 Epas1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25487 Epas1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Epas1 NCBI NCBI:2034