Epha3 - Eph receptor A3 Gene

Also Known as EK4; Hek; Cek4; ETK1; End3; Hek4; Mek4; Tyro4

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13837

Summary

Enables Ephrin Receptor activity and growth factor binding activity. Involved in several processes, including axonal fasciculation; Ephrin Receptor signaling pathway; and synaptic membrane adhesion. Acts upstream of or within cellular response to follicle-stimulating hormone stimulus; negative regulation of neuron projection development; and regulation of cell migration. Located in GABA-ergic synapse. Is active in presynapse. Is expressed in several structures, including alimentary system; branchial arch; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in pancreatic Cancer. Orthologous to human EphA3 (EPH receptor A3). [provided by Alliance of Genome Resources, Apr 2022]

Epha3 Products (2)

mRNA Protein Name
NM_001362452.1 NP_001349381.1 ephrin type-A receptor 3 isoform 2 precursor
NM_010140.4 NP_034270.1 ephrin type-A receptor 3 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ephrin receptor activity IDA
IDA: Inferred from direct assay
15145949 MGI
enables growth factor binding IPI
IPI: Inferred from physical interaction
22568954 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
19505147 MGI
Biological Process GO Annotation Evidence References Source
involved in cell migration IMP
IMP: Inferred from mutant phenotype
17046737 MGI
acts upstream of or within cellular response to follicle-stimulating hormone stimulus IDA
IDA: Inferred from direct assay
23242526 MGI
involved in endocardial cushion development IMP
IMP: Inferred from mutant phenotype
17046737 MGI
involved in ephrin receptor signaling pathway IDA
IDA: Inferred from direct assay
21135139 MGI
involved in fasciculation of motor neuron axon IMP
IMP: Inferred from mutant phenotype
18403711 MGI
involved in fasciculation of sensory neuron axon IMP
IMP: Inferred from mutant phenotype
21791286 MGI
NOT involved in motor neuron axon guidance IMP
IMP: Inferred from mutant phenotype
17046737 MGI
acts upstream of or within negative regulation of neuron projection development IDA
IDA: Inferred from direct assay
19505147 MGI
acts upstream of or within regulation of cell migration IGI
IGI: Inferred from genetic interaction
19505147 MGI
involved in regulation of epithelial to mesenchymal transition IMP
IMP: Inferred from mutant phenotype
17046737 MGI
involved in synaptic membrane adhesion IDA
IDA: Inferred from direct assay
22275477 MGI
involved in synaptic membrane adhesion IMP
IMP: Inferred from mutant phenotype
22275477 MGI
Cellular Component GO Annotation Evidence References Source
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
22275477 MGI
is active in GABA-ergic synapse IMP
IMP: Inferred from mutant phenotype
22275477 MGI
is active in presynapse IDA
IDA: Inferred from direct assay
22275477 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ephrin type-A receptor 3

  • EPH-like kinase 4

  • tyrosine-protein kinase TYRO4

  • tyrosine-protein kinase receptor ETK1

Recombinant Epha3 Proteins

Cat. No. Product Name Accession Purity
HY-P75738 EphA3 Protein, Mouse (sf9) Q8BRB1 (G569-V984) ≥ 85%, as determined by reducing SDS-PAGE.
HY-P75739 EphA3 Protein, Mouse (sf9, His-GST) Q8BRB1 (G569-V984) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P75740 EphA3 Protein, Mouse (HEK293, Fc) Q8BRB1 (M1-H541) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P75741 EphA3 Protein, Mouse (HEK293, His) Q8BRB1 (E21-H541) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-18832 AWL-II-38.3 Inhibitor 99.68% Unkown
HY-148061 DB1113 99.86% Unkown
HY-148063 DB0614 99.92% Unkown
HY-170517 PKMYT1-IN-8 Inhibitor 99.31% Unkown
HY-146375 UniPR505 Antagonist 99.68% Unkown
HY-P10579 123B9 Agonist 99.67% Unkown
HY-10654 EphB4-IN-2 Inhibitor / Unkown
HY-RS04427 EPHA3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18813 Epha3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25303 Epha3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Epha3 NCBI NCBI:2042