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APOOL - apolipoprotein O like Gene

Also Known as Mic27; CXorf33; FAM121A; MICOS27; UNQ8193

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 139322

About APOOL

Cytogenetic location: Xq21.1 Genomic coordinates (GRCh38): X:85,003,877-85,093,315 (from NCBI)

This gene has 1 transcript (splice variant), 209 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 7.7), thyroid (RPKM 6.2) and 25 other tissues.

Summary

This gene encodes a protein which contains an Apolipoprotein O superfamily domain. This domain is found on proteins in circulating lipoprotein complexes. [provided by RefSeq, Sep 2011]

APOOL Products (1)

mRNA	Protein	Name
NM_198450.6	NP_940852.3	MICOS complex subunit MIC27 precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25764979	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of MICOS complex	IDA IDA: Inferred from direct assay	25781180	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	25781180	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

APOOL Protein Structure

ApoO

0
100
200
268 a.a.

Protein Preferred Names	Protein Names
MICOS complex subunit MIC27	AAIR8193

Related Diseases

Diseases	Alias
Combined Oxidative Phosphorylation Deficiency 37	COXPD37
Deafness, X-Linked 7	X-Linked External Auditory Canal Atresia-Dilated Internal Auditory Canal-Facial Dysmorphism Syndrome DFNX7 X-Linked Deafness 7 Deafness, X-Linked, 7
Barth Syndrome	3-Methylglutaconic Aciduria Type 2 BTHS Cardioskeletal Myopathy With Neutropenia And Abnormal Mitochondria Mga Type Ii Mga2 Mgca2 Mga Type 2 3-Methylglutaconic Aciduria Type Ii 3-Methylglutaconic Aciduria, Type Ii Mga, Type Ii 3-Methylglutaconicaciduria Type 2 3-Methylglutaconicaciduria Type Ii Taz Defect 3 Methylglutaconic Aciduria, Type Ii Dnajc19 Defect Cardioskeletal Myopathy-Neutropenia Syndrome X-Linked Cardioskeletal Myopathy And Neutropenia 3-Alpha-Methylglutaconic Aciduria Type 2 Agm2 Cardioskeletal Myopathy-Neutropenia Invm Left Ventricular Non-Compaction Isolated X-Linked Non-Compaction Of Left Ventricular Myocardium Isolated X-Linked Agammaglobulinemia 2, Autosomal Recessive

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00862	APOOL Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	APOOL	RGD	RGD:1549725
Mus musculus	APOOL	MGD	MGI:1915367
Canis familiaris	APOOL	VGNC	VGNC:38009
Macaca mulatta	APOOL	VGNC	VGNC:97734
Bos taurus	APOOL	VGNC	VGNC:26036
Others	APOOL	NCBI