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Fgf13 - fibroblast growth factor 13 Gene

Also Known as Fhf2; Fgf1c

Species: Mus musculus

Gene Type: protein coding

Gene ID: 14168

Summary

Enables Sodium Channel regulator activity; transmembrane transporter binding activity; and tubulin binding activity. Involved in several processes, including learning or memory; nervous system development; and regulation of cardiac muscle cell action potential involved in regulation of contraction. Located in several cellular components, including growth cone; intercalated disc; and lateral plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; peripheral nervous system; and sensory organ. Used to study intellectual disability. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy. Orthologous to human FGF13 (Fibroblast Growth Factor 13). [provided by Alliance of Genome Resources, Apr 2022]

Fgf13 Products (7)

mRNA	Protein	Name
NM_001290414.1	NP_001277343.1	fibroblast growth factor 13 isoform 2
NM_001290415.1	NP_001277344.1	fibroblast growth factor 13 isoform 3
NM_001356335.1	NP_001343264.1	fibroblast growth factor 13 isoform 4
NM_001411971.1	NP_001398900.1	fibroblast growth factor 13 isoform 2
NM_001411972.1	NP_001398901.1	fibroblast growth factor 13 isoform 2
NM_001411973.1	NP_001398902.1	fibroblast growth factor 13 isoform 2
NM_010200.3	NP_034330.2	fibroblast growth factor 13 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables beta-tubulin binding	IDA IDA: Inferred from direct assay	22726441	MGI
enables microtubule binding	IDA IDA: Inferred from direct assay	22726441	MGI
enables sodium channel regulator activity	IMP IMP: Inferred from mutant phenotype	21817159	MGI
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	21817159	MGI

Biological Process GO Annotation	Evidence	References	Source
NOT involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	22726441	MGI
acts upstream of or within branching morphogenesis of a nerve	IMP IMP: Inferred from mutant phenotype	34184986	MGI
involved in cerebral cortex cell migration	IMP IMP: Inferred from mutant phenotype	22726441	MGI
NOT involved in establishment of neuroblast polarity	IMP IMP: Inferred from mutant phenotype	22726441	MGI
involved in establishment of neuroblast polarity	IMP IMP: Inferred from mutant phenotype	22726441	MGI
involved in hippocampus development	IMP IMP: Inferred from mutant phenotype	22726441	MGI
involved in inhibitory synapse assembly	IMP IMP: Inferred from mutant phenotype	30679375	MGI
involved in learning	IMP IMP: Inferred from mutant phenotype	22726441	MGI
acts upstream of or within learning or memory	IMP IMP: Inferred from mutant phenotype	34184986	MGI
involved in memory	IMP IMP: Inferred from mutant phenotype	22726441	MGI
involved in microtubule polymerization	IMP IMP: Inferred from mutant phenotype	22726441	MGI
involved in negative regulation of collateral sprouting	IMP IMP: Inferred from mutant phenotype	22726441	MGI
involved in negative regulation of microtubule depolymerization	IMP IMP: Inferred from mutant phenotype	22726441	MGI
acts upstream of or within neurogenesis	IMP IMP: Inferred from mutant phenotype	34010636	MGI
NOT involved in neuron migration	IMP IMP: Inferred from mutant phenotype	22726441	MGI
acts upstream of or within neuron migration	IMP IMP: Inferred from mutant phenotype	34184986	MGI
involved in neuron migration	IMP IMP: Inferred from mutant phenotype	22726441	MGI
involved in protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	21817159	MGI
involved in regulation of cardiac muscle cell action potential involved in regulation of contraction	IMP IMP: Inferred from mutant phenotype	21817159	MGI
involved in sodium ion transport	IMP IMP: Inferred from mutant phenotype	21817159	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in axon	IDA IDA: Inferred from direct assay	22726441	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	21817159	MGI
located in cytosol	IDA IDA: Inferred from direct assay	10644718	MGI
located in dendrite	IDA IDA: Inferred from direct assay	22726441	MGI
located in filopodium	IDA IDA: Inferred from direct assay	22726441	MGI
located in growth cone	IDA IDA: Inferred from direct assay	22726441	MGI
located in intercalated disc	IDA IDA: Inferred from direct assay	21817159	MGI
located in lateral plasma membrane	IDA IDA: Inferred from direct assay	21817159	MGI
located in microtubule	IDA IDA: Inferred from direct assay	22726441	MGI
located in neuron projection	IDA IDA: Inferred from direct assay	22726441	MGI
located in nucleus	IDA IDA: Inferred from direct assay	10644718	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	21817159	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
fibroblast growth factor 13	fibroblast growth factor 1c fibroblast growth factor homologous factor 2

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04890	FGF13 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04893	FGF17 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174708	Human FGF13 mRNA		/	Unkown
HY-RS19002	Fgf13 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25491	Fgf13 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fgf13	NCBI	NCBI:2258