Fgfr1 - fibroblast growth factor receptor 1 Gene

Also Known as FLG; Fr1; MFR; Eask; Hspy; Flt-2; c-fgr; FGFR-I; Fgfr-1; bFGF-R-1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 14182

About Fgfr1

Chromosome 8: 26,003,670-26,065,734 forward strand.GRCm39:CM001001.3

This gene has 19 transcripts (splice variants), 293 orthologues, 53 paralogues and is associated with 206 phenotypes. Broad expression in limb E14.5 (RPKM 38.2), adrenal adult (RPKM 35.4) and 23 other tissues.

Summary

Enables SH2 domain binding activity; Fibroblast Growth Factor binding activity; and fibroblast growth factor-activated receptor activity. Involved in forebrain development; negative regulation of transcription by RNA polymerase II; and positive regulation of cell cycle. Acts upstream of or within several processes, including animal organ development; positive regulation of cell population proliferation; and regulation of animal organ morphogenesis. Located in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Used to study Pfeiffer syndrome and otitis media. Human ortholog(s) of this gene implicated in several diseases, including Jackson-Weiss syndrome; bone disease (multiple); cleft lip; hematologic Cancer (multiple); and hypogonadotropic hypogonadism (multiple). Orthologous to human FGFR1 (Fibroblast Growth Factor receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Fgfr1 Products (3)

mRNA	Protein	Name
NM_001079908.3	NP_001073377.1	fibroblast growth factor receptor 1 isoform 2 precursor
NM_010206.4	NP_034336.2	fibroblast growth factor receptor 1 isoform 1 precursor
NM_001079909.3	NP_001073378.1	fibroblast growth factor receptor 1 isoform 3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables SH2 domain binding	IPI IPI: Inferred from physical interaction	19307307	MGI
enables fibroblast growth factor binding	IDA IDA: Inferred from direct assay	2161540	MGI
enables fibroblast growth factor binding	IPI IPI: Inferred from physical interaction	17086194	MGI
enables fibroblast growth factor receptor activity	IDA IDA: Inferred from direct assay	2161540	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16399079	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within angiogenesis	IGI IGI: Inferred from genetic interaction	16778080	MGI
acts upstream of or within auditory receptor cell development	IMP IMP: Inferred from mutant phenotype	15630379	MGI
acts upstream of or within blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	10373225	MGI
acts upstream of or within brain development	IMP IMP: Inferred from mutant phenotype	12682014	MGI
acts upstream of or within branching involved in salivary gland morphogenesis	IMP IMP: Inferred from mutant phenotype	12421715	MGI
involved in calcium ion homeostasis	IGI IGI: Inferred from genetic interaction	23523568	MGI
acts upstream of cardiac muscle cell proliferation	IGI IGI: Inferred from genetic interaction	15621532	MGI
acts upstream of or within cell maturation	IMP IMP: Inferred from mutant phenotype	10373225	MGI
acts upstream of cell population proliferation	IGI IGI: Inferred from genetic interaction	16778080	MGI
acts upstream of or within cell projection assembly	IDA IDA: Inferred from direct assay	23034183	MGI
acts upstream of or within cell projection assembly	IMP IMP: Inferred from mutant phenotype	23034183	MGI
involved in cementum mineralization	IDA IDA: Inferred from direct assay	31059863	MGI
involved in cementum mineralization	IMP IMP: Inferred from mutant phenotype	31059863	MGI
acts upstream of or within chondrocyte differentiation	IGI IGI: Inferred from genetic interaction	17544391	MGI
involved in diphosphate metabolic process	IDA IDA: Inferred from direct assay	31059863	MGI
involved in diphosphate metabolic process	IMP IMP: Inferred from mutant phenotype	31059863	MGI
acts upstream of or within ear development	IMP IMP: Inferred from mutant phenotype	26234751	MGI
acts upstream of or within embryonic limb morphogenesis	IMP IMP: Inferred from mutant phenotype	16207751	MGI
acts upstream of or within fibroblast growth factor receptor signaling pathway	IGI IGI: Inferred from genetic interaction	2161540	MGI
involved in fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development	IMP IMP: Inferred from mutant phenotype	20410112	MGI
involved in gene expression	IDA IDA: Inferred from direct assay	31059863	MGI
involved in gene expression	IMP IMP: Inferred from mutant phenotype	31059863	MGI
acts upstream of or within generation of neurons	IMP IMP: Inferred from mutant phenotype	16172976	MGI
acts upstream of or within in utero embryonic development	IGI IGI: Inferred from genetic interaction	17687036	MGI
acts upstream of or within inner ear morphogenesis	IMP IMP: Inferred from mutant phenotype	12194867	MGI
acts upstream of or within lung development	IGI IGI: Inferred from genetic interaction	16540513	MGI
acts upstream of or within lung development	IMP IMP: Inferred from mutant phenotype	15576401	MGI
acts upstream of or within lung-associated mesenchyme development	IGI IGI: Inferred from genetic interaction	18533146	MGI
acts upstream of or within mesenchymal cell differentiation	IGI IGI: Inferred from genetic interaction	16442091	MGI
acts upstream of mesenchymal cell proliferation	IGI IGI: Inferred from genetic interaction	16540513	MGI
acts upstream of mesenchymal cell proliferation	IMP IMP: Inferred from mutant phenotype	18191119	MGI
acts upstream of or within midbrain development	IGI IGI: Inferred from genetic interaction	17687036	MGI
acts upstream of or within midbrain development	IMP IMP: Inferred from mutant phenotype	17687036	MGI
acts upstream of or within middle ear morphogenesis	IMP IMP: Inferred from mutant phenotype	15630379	MGI
acts upstream of or within negative regulation of fibroblast growth factor production	IGI IGI: Inferred from genetic interaction	24259513	MGI
acts upstream of or within negative regulation of gene expression	IGI IGI: Inferred from genetic interaction	24259513	MGI
acts upstream of or within negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	18191119	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20410112	MGI
acts upstream of neuron projection development	IGI IGI: Inferred from genetic interaction	21389209	MGI
involved in orbitofrontal cortex development	IMP IMP: Inferred from mutant phenotype	20410112	MGI
acts upstream of or within organ induction	IMP IMP: Inferred from mutant phenotype	15576401	MGI
acts upstream of or within outer ear morphogenesis	IMP IMP: Inferred from mutant phenotype	15630379	MGI
acts upstream of or within paraxial mesoderm development	IGI IGI: Inferred from genetic interaction	16943278	MGI
acts upstream of or within positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway	IGI IGI: Inferred from genetic interaction	18187602	MGI
acts upstream of or within positive regulation of cardiac muscle cell proliferation	IGI IGI: Inferred from genetic interaction	15621532	MGI
involved in positive regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	20410112	MGI
acts upstream of or within positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	2161540	MGI
acts upstream of or within positive regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	18187602	MGI
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	20410112	MGI
acts upstream of or within positive regulation of mesenchymal cell proliferation	IGI IGI: Inferred from genetic interaction	16540513	MGI
acts upstream of or within positive regulation of mesenchymal cell proliferation	IMP IMP: Inferred from mutant phenotype	18191119	MGI
acts upstream of or within positive regulation of mitotic cell cycle DNA replication	IDA IDA: Inferred from direct assay	2161540	MGI
acts upstream of or within positive regulation of neuron projection development	IGI IGI: Inferred from genetic interaction	21389209	MGI
acts upstream of or within positive regulation of parathyroid hormone secretion	IGI IGI: Inferred from genetic interaction	24259513	MGI
acts upstream of or within positive regulation of stem cell proliferation	IGI IGI: Inferred from genetic interaction	16540513	MGI
acts upstream of or within positive regulation of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	18191119	MGI
acts upstream of or within regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	IDA IDA: Inferred from direct assay	18559345	MGI
acts upstream of or within regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	12194867	MGI
acts upstream of or within regulation of extrinsic apoptotic signaling pathway in absence of ligand	IMP IMP: Inferred from mutant phenotype	16207751	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	18799682	MGI
acts upstream of or within regulation of lateral mesodermal cell fate specification	IGI IGI: Inferred from genetic interaction	16943278	MGI
acts upstream of or within regulation of phosphate transport	IGI IGI: Inferred from genetic interaction	24259513	MGI
acts upstream of or within regulation of phosphorus metabolic process	IGI IGI: Inferred from genetic interaction	24259513	MGI
involved in regulation of postsynaptic density assembly	IDA IDA: Inferred from direct assay	32324534	MGI
involved in regulation of postsynaptic density assembly	IMP IMP: Inferred from mutant phenotype	32324534	MGI
involved in response to sodium phosphate	IDA IDA: Inferred from direct assay	23523568	MGI
involved in response to sodium phosphate	IGI IGI: Inferred from genetic interaction	23523568	MGI
acts upstream of or within salivary gland morphogenesis	IMP IMP: Inferred from mutant phenotype	12421715	MGI
acts upstream of or within sensory perception of sound	IMP IMP: Inferred from mutant phenotype	15630379	MGI
acts upstream of or within stem cell differentiation	IGI IGI: Inferred from genetic interaction	16442091	MGI
acts upstream of stem cell proliferation	IGI IGI: Inferred from genetic interaction	16540513	MGI
acts upstream of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	18191119	MGI
acts upstream of or within ureteric bud development	IGI IGI: Inferred from genetic interaction	16442091	MGI
involved in ventricular zone neuroblast division	IMP IMP: Inferred from mutant phenotype	20410112	MGI
acts upstream of or within vitamin D3 metabolic process	IGI IGI: Inferred from genetic interaction	24259513	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	32324534	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	32324534	MGI
located in plasma membrane	IPI IPI: Inferred from physical interaction	2161540	MGI
is active in postsynapse	IDA IDA: Inferred from direct assay	32324534	MGI
is active in postsynapse	IMP IMP: Inferred from mutant phenotype	32324534	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Fgfr1 Protein Structure

IgI_1_FGFR

IgI_2_FGFR

PTKc_FGFR1

0
200
400
600
822 a.a.

Protein Preferred Names	Protein Names
fibroblast growth factor receptor 1	basic fibroblast growth factor receptor 1 proto-oncogene c-Fgr

Recombinant Fgfr1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75767	FGFR-1 Protein, Mouse (HEK293, Fc)	P16092-1 (M1-E376)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P75768	FGFR-1 Protein, Mouse (HEK293, His)	P16092 (R22-E376)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99930	Efruxifermin	Activator	98.58%	Phase 3

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-163705	BR-cpd7	Degrader	98.01%	Unkown
HY-165298	DGY-09-192	Degrader	99.50%	Unkown
HY-184094	Risimtinib	Inhibitor	/	Unkown
HY-135435	SU10944	Inhibitor	/	Unkown
HY-P11852	NOTA-cRY9M		/	Unkown
HY-183780	FGFR-IN-27	Inhibitor	/	Unkown
HY-181752	FGFR3-IN-12	Inhibitor	/	Unkown
HY-10321G	PD173074 (GMP)	Inhibitor	/	Unkown
HY-184250	FGFR-IN-28	Inhibitor	/	Unkown
HY-184598	CYB-5067	Degrader	/	Unkown
HY-160013	FGFR-IN-12	Inhibitor	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990252	Anti-Mouse Delta-like protein 4/DLL4 Antibody (HMD4-2)	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fgfr1	NCBI	NCBI:2260