Flt3l - FMS-like tyrosine kinase 3 ligand Gene

Also Known as Ly72L; Flt3lg

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14256

Summary

Enables identical protein binding activity and receptor tyrosine kinase binding activity. Acts upstream of or within several processes, including positive regulation of cell population proliferation; positive regulation of nitrogen compound metabolic process; and regulation of leukocyte activation. Located in cell surface and extracellular space. Is intrinsic component of external side of plasma membrane. Is expressed in several structures, including central nervous system; liver; retina; spleen; and yolk sac. Human ortholog(s) of this gene implicated in colon carcinoma; glioblastoma; and high grade glioma. Orthologous to human FLT3LG (fms related receptor tyrosine kinase 3 ligand). [provided by Alliance of Genome Resources, Apr 2022]

Flt3l Products (8)

mRNA Protein Name
NM_001402831.1 NP_001389760.1 fms-related tyrosine kinase 3 ligand isoform a precursor
NM_001402832.1 NP_001389761.1 fms-related tyrosine kinase 3 ligand isoform b precursor
NM_001402833.1 NP_001389762.1 fms-related tyrosine kinase 3 ligand isoform b precursor
NM_001402834.1 NP_001389763.1 fms-related tyrosine kinase 3 ligand isoform b precursor
NM_001402835.1 NP_001389764.1 fms-related tyrosine kinase 3 ligand isoform c precursor
NM_001402836.1 NP_001389765.1 fms-related tyrosine kinase 3 ligand isoform c precursor
NM_001402837.1 NP_001389766.1 fms-related tyrosine kinase 3 ligand isoform d
NM_013520.4 NP_038548.3 fms-related tyrosine kinase 3 ligand isoform b precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables receptor tyrosine kinase binding IDA
IDA: Inferred from direct assay
7531700 MGI
enables receptor tyrosine kinase binding IPI
IPI: Inferred from physical interaction
7505204 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within homeostasis of number of cells within a tissue IDA
IDA: Inferred from direct assay
21048959 MGI
acts upstream of or within homeostasis of number of cells within a tissue IGI
IGI: Inferred from genetic interaction
21048959 MGI
acts upstream of or within lymphocyte differentiation IMP
IMP: Inferred from mutant phenotype
12387740 MGI
acts upstream of natural killer cell differentiation IMP
IMP: Inferred from mutant phenotype
14607906 MGI
acts upstream of or within negative regulation of apoptotic process in bone marrow cell IGI
IGI: Inferred from genetic interaction
21048959 MGI
acts upstream of or within positive regulation of cell cycle IDA
IDA: Inferred from direct assay
21048959 MGI
acts upstream of or within positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
7505204 MGI
acts upstream of or within positive regulation of cell proliferation in bone marrow IGI
IGI: Inferred from genetic interaction
21048959 MGI
acts upstream of or within positive regulation of myoblast differentiation IMP
IMP: Inferred from mutant phenotype
23844157 MGI
acts upstream of or within positive regulation of myoblast fusion IMP
IMP: Inferred from mutant phenotype
23844157 MGI
acts upstream of or within positive regulation of natural killer cell differentiation IMP
IMP: Inferred from mutant phenotype
14607906 MGI
acts upstream of or within positive regulation of osteoclast proliferation IDA
IDA: Inferred from direct assay
21048959 MGI
acts upstream of or within positive regulation of osteoclast proliferation IGI
IGI: Inferred from genetic interaction
21048959 MGI
acts upstream of or within positive regulation of protein phosphorylation IGI
IGI: Inferred from genetic interaction
20360400 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
21048959 MGI
acts upstream of protein phosphorylation IGI
IGI: Inferred from genetic interaction
20360400 MGI
acts upstream of or within regulation of myeloid dendritic cell activation IMP
IMP: Inferred from mutant phenotype
23913046 MGI
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
7630197 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
7505204 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
7505204 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

fms-related tyrosine kinase 3 ligand

  • flt3 ligand

Recombinant Flt3l Proteins

Cat. No. Product Name Accession Purity
HY-P7354 FLT3LG Protein, Mouse (CHO, His) P49772-1 (G27-R188) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P70563 FLT3LG Protein, Mouse (HEK293, His) P49772-1 (G27-R188) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73067 FLT3LG Protein, Mouse (HEK293, Fc) P49772-1 (G27-Q189) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P700177AF Animal-Free FLT3LG Protein, Mouse (His) P49772 (G27-R188) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04993 FLT3LG Human Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991208 Flt-3L-Ig (hum/hum) 98% Unkown