Folr1 - folate receptor 1 (adult) Gene

Also Known as FBP1; Folbp1; Folbp-1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 14275

Summary

Predicted to enable carboxylic acid binding activity; folic acid receptor activity; and signaling receptor activity. Involved in circulatory system development; nervous system development; and regulation of signal transduction. Acts upstream of or within folic acid metabolic process. Predicted to be located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and brush border membrane. Predicted to be anchored component of plasma membrane. Predicted to be anchored component of external side of plasma membrane. Is expressed in several structures, including brain; early conceptus; genitourinary system; gut; and retina. Human ortholog(s) of this gene implicated in cerebral folate receptor alpha deficiency. Orthologous to human FOLR1 (folate receptor alpha). [provided by Alliance of Genome Resources, Apr 2022]

Folr1 Products (16)

mRNA	Protein	Name
NM_001252552.2	NP_001239481.1	folate receptor alpha precursor
NM_001252553.2	NP_001239482.1	folate receptor alpha precursor
NM_001252554.2	NP_001239483.1	folate receptor alpha precursor
NM_001412428.1	NP_001399357.1	folate receptor alpha precursor
NM_001412429.1	NP_001399358.1	folate receptor alpha precursor
NM_001412430.1	NP_001399359.1	folate receptor alpha precursor
NM_001412431.1	NP_001399360.1	folate receptor alpha precursor
NM_001412432.1	NP_001399361.1	folate receptor alpha precursor
NM_001412433.1	NP_001399362.1	folate receptor alpha precursor
NM_001412434.1	NP_001399363.1	folate receptor alpha precursor
NM_001412435.1	NP_001399364.1	folate receptor alpha precursor
NM_001412436.1	NP_001399365.1	folate receptor alpha precursor
NM_001412437.1	NP_001399366.1	folate receptor alpha precursor
NM_001412438.1	NP_001399367.1	folate receptor alpha precursor
NM_001412439.1	NP_001399368.1	folate receptor alpha precursor
NM_008034.4	NP_032060.2	folate receptor alpha precursor

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Références	Source
involved in anterior neural tube closure	IMP IMP: Inferred from mutant phenotype	17286298	MGI
involved in axon regeneration	IMP IMP: Inferred from mutant phenotype	20424322	MGI
involved in cardiac neural crest cell migration involved in outflow tract morphogenesis	IMP IMP: Inferred from mutant phenotype	17286298	MGI
acts upstream of or within folic acid metabolic process	IMP IMP: Inferred from mutant phenotype	12854656	MGI
involved in heart looping	IMP IMP: Inferred from mutant phenotype	17286298	MGI
involved in neural crest cell migration involved in heart formation	IMP IMP: Inferred from mutant phenotype	17286298	MGI
involved in pharyngeal arch artery morphogenesis	IMP IMP: Inferred from mutant phenotype	17286298	MGI
involved in regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	21649587	MGI
involved in regulation of transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	21649587	MGI
involved in response to axon injury	IMP IMP: Inferred from mutant phenotype	20424322	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
folate receptor alpha	FR-alpha folate-binding protein 1

Recombinant Folr1 Proteins

Cat. No.	Nom du produit	Accession	Pureté
HY-P70344	FOLR1 Protein, Mouse (HEK293, His)	P35846 (T25-S232)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78871	FOLR1 Protein, Mouse (Biotinylated, HEK293, His-Avi)	P35846 (T25-S232)	≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Phase
HY-132258A	Mirvetuximab soravtansine (solution)		98.20%	Phase 3

Inhibitory Antibodies (1)

Cat. No.	Nom du produit	Effect	Pureté	Phase
HY-P99225A	Mirvetuximab (powder)		99.31%	Phase 3

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS05029	FOLR1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05030	FOLR2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16758	Folr1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23197	Folr1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (7)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-P99225	Mirvetuximab		99.88%	Unkown
HY-P990941	Rinatabart		99.47%	Unkown
HY-P992112	Eliroptamig	Inhibitor	/	Unkown
HY-P990935	Opugotamig		99.67%	Unkown
HY-P991695	Lazatatug	Inhibitor	/	Unkown
HY-P992004	KHK2805	Inhibitor	/	Unkown
HY-P990417	Anti-FOLR1/FRA Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Folr1	NCBI	NCBI:2348