Fzd5 - frizzled class receptor 5 Gene

Also Known as Fz5; Fz-5; mFz5; 5330434N09Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14367

Summary

Enables Wnt-protein binding activity. Involved in camera-type eye development; canonical Wnt signaling pathway; and positive regulation of cytokine production. Acts upstream of or within several processes, including chorionic trophoblast cell differentiation; embryonic organ development; and positive regulation of nitrogen compound metabolic process. Located in several cellular components, including Golgi apparatus; bicellular tight junction; and perinuclear region of cytoplasm. Colocalizes with early endosome. Is expressed in several structures, including alimentary system; early conceptus; future brain; genitourinary system; and sensory organ. Orthologous to human FZD5 (Frizzled class receptor 5). [provided by Alliance of Genome Resources, Apr 2022]

Fzd5 Products (2)

mRNA Protein Name
NM_001042659.2 NP_001036124.1 frizzled-5 precursor
NM_022721.4 NP_073558.2 frizzled-5 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables Wnt-protein binding IPI
IPI: Inferred from physical interaction
18606138 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11520064 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within T cell differentiation in thymus IMP
IMP: Inferred from mutant phenotype
11265645 MGI
acts upstream of or within Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
11092808 MGI
acts upstream of or within angiogenesis IMP
IMP: Inferred from mutant phenotype
11092808 MGI
acts upstream of or within apoptotic process involved in morphogenesis IMP
IMP: Inferred from mutant phenotype
18791178 MGI
acts upstream of or within branching involved in labyrinthine layer morphogenesis IMP
IMP: Inferred from mutant phenotype
23610556 MGI
involved in canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
11265645 MGI
acts upstream of or within chorionic trophoblast cell differentiation IMP
IMP: Inferred from mutant phenotype
23610556 MGI
acts upstream of or within embryonic camera-type eye development IMP
IMP: Inferred from mutant phenotype
18791178 MGI
involved in embryonic camera-type eye morphogenesis IMP
IMP: Inferred from mutant phenotype
18832390 MGI
acts upstream of or within glandular epithelial cell maturation IMP
IMP: Inferred from mutant phenotype
15778706 MGI
acts upstream of or within intestinal epithelial cell maturation IMP
IMP: Inferred from mutant phenotype
15778706 MGI
acts upstream of or within labyrinthine layer blood vessel development IMP
IMP: Inferred from mutant phenotype
11092808 MGI
acts upstream of or within negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
18791178 MGI
acts upstream of or within positive regulation of JUN kinase activity IDA
IDA: Inferred from direct assay
15195140 MGI
involved in positive regulation of interleukin-1 beta production IGI
IGI: Inferred from genetic interaction
21857966 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
23610556 MGI
involved in positive regulation of tumor necrosis factor production IGI
IGI: Inferred from genetic interaction
21857966 MGI
acts upstream of or within post-embryonic camera-type eye development IMP
IMP: Inferred from mutant phenotype
18791178 MGI
involved in post-embryonic camera-type eye development IMP
IMP: Inferred from mutant phenotype
18832390 MGI
acts upstream of or within regulation of bicellular tight junction assembly IMP
IMP: Inferred from mutant phenotype
23610556 MGI
acts upstream of or within regulation of chorionic trophoblast cell proliferation IMP
IMP: Inferred from mutant phenotype
23610556 MGI
acts upstream of or within syncytiotrophoblast cell differentiation involved in labyrinthine layer development IMP
IMP: Inferred from mutant phenotype
23610556 MGI
acts upstream of or within vasculature development IMP
IMP: Inferred from mutant phenotype
18791178 MGI
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
11520064 MGI
located in bicellular tight junction IDA
IDA: Inferred from direct assay
23610556 MGI
colocalizes with early endosome IDA
IDA: Inferred from direct assay
16890161 MGI
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
11520064 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
11520064 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

frizzled-5

  • frizzled homolog 5

Fzd5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Fzd5 Q9EQD0 Gopc Mus musculus Q8BH60
Anti Tag CoIP
11520064
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Fzd5 Proteins

Cat. No. Product Name Accession Purity
HY-P74136 Frizzled-5 Protein, Mouse (CHO, Fc) Q9EQD0 (A27-P167) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0836 Jervine 99.28% Unkown
HY-D1474 WNT7A-IN-1 sodium Inhibitor 98.05% Unkown
HY-170411 WNT7A-IN-1 Inhibitor 99.66% Unkown
HY-RS05181 FZD5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-N0836A Jervine hydriodide / Unkown
HY-RS18360 Fzd5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24839 Fzd5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992229 Anti-FZD5 Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fzd5 NCBI NCBI:7855