Lpar1 - lysophosphatidic acid receptor 1 Gene

Also Known as Edg2; Kdt2; lpA1; vzg-1; Gpcr26

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14745

About Lpar1

Chromosome 4: 58,435,255-58,553,898 reverse strand.GRCm39:CM000997.3

This gene has 8 transcripts (splice variants), 216 orthologues, 18 paralogues and is associated with 28 phenotypes. Ubiquitous expression in limb E14.5 (RPKM 2.9), colon adult (RPKM 17.1) and 24 other tissues.

Summary

Enables PDZ domain binding activity and lysophosphatidic acid receptor activity. Involved in several processes, including activation of Phospholipase C activity; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; and positive regulation of stress fiber assembly. Acts upstream of or within bleb assembly; positive regulation of MAPK cascade; and positive regulation of Rho protein signal transduction. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Orthologous to human LPAR1 (lysophosphatidic acid receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Lpar1 Products (3)

mRNA Protein Name
NM_172989.1 NP_766577.1 lysophosphatidic acid receptor 1 isoform 1
NM_010336.2 NP_034466.2 lysophosphatidic acid receptor 1 isoform 1
NM_001290486.1 NP_001277415.1 lysophosphatidic acid receptor 1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables PDZ domain binding IPI
IPI: Inferred from physical interaction
15755723 MGI
enables lysophosphatidic acid receptor activity IDA
IDA: Inferred from direct assay
8922387 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15755723 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
15755723 MGI
involved in G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
8922387 MGI
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
11040035 MGI
acts upstream of or within bleb assembly IGI
IGI: Inferred from genetic interaction
17135244 MGI
involved in negative regulation of neuron projection development IDA
IDA: Inferred from direct assay
11040035 MGI
involved in negative regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
9600933 MGI
acts upstream of or within positive regulation of MAPK cascade IDA
IDA: Inferred from direct assay
15755723 MGI
involved in positive regulation of MAPK cascade IDA
IDA: Inferred from direct assay
11040035 MGI
acts upstream of or within positive regulation of Rho protein signal transduction IDA
IDA: Inferred from direct assay
15755723 MGI
involved in positive regulation of Rho protein signal transduction IDA
IDA: Inferred from direct assay
11040035 MGI
involved in positive regulation of Rho protein signal transduction IMP
IMP: Inferred from mutant phenotype
9600933 MGI
involved in positive regulation of stress fiber assembly IDA
IDA: Inferred from direct assay
9600933 MGI
involved in regulation of cell shape IDA
IDA: Inferred from direct assay
8922387 MGI
involved in regulation of cell shape IMP
IMP: Inferred from mutant phenotype
9600933 MGI
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
8922387 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Lpar1 Protein Structure

7tmA_LPAR1_Edg2

7tmA_LPAR1_Edg2: cd15344 (49 - 321)

7tmA_LPAR1_Edg2

7tmA_LPAR1_Edg2: cd15344 (50 - 76)

7tmA_LPAR1_Edg2

7tmA_LPAR1_Edg2: cd15344 (83 - 108)

7tmA_LPAR1_Edg2

7tmA_LPAR1_Edg2: cd15344 (120 - 150)

7tmA_LPAR1_Edg2

7tmA_LPAR1_Edg2: cd15344 (161 - 181)

7tmA_LPAR1_Edg2

7tmA_LPAR1_Edg2: cd15344 (201 - 230)

7tmA_LPAR1_Edg2

7tmA_LPAR1_Edg2: cd15344 (250 - 280)

7tmA_LPAR1_Edg2

7tmA_LPAR1_Edg2: cd15344 (289 - 314)

  • 0
  • 100
  • 200
  • 300
  • 364 a.a.
Protein Preferred Names Protein Names

lysophosphatidic acid receptor 1

  • G-protein coupled receptor 26

  • LPA receptor 1

  • endothelial differentiation lysophosphatidic acid G-protein-coupled receptor 2

  • lysophosphatidic acid receptor Edg-2

  • rec1.3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-16039 AM095 Antagonist 99.72% Unkown
HY-15706 H2L 5765834 Antagonist 98.66% Unkown
HY-117444 ONO-9780307 Inhibitor 99.94% Unkown
HY-117959 TAK-615 Inhibitor 98.07% Unkown
HY-115450 ONO-0300302 Antagonist 98.02% Unkown
HY-124072 HL001 Antagonist 98.90% Unkown
HY-181931 Autotaxin-IN-8 Inhibitor / Unkown
HY-178845 Decyl phosphate Modulator / Unkown
HY-W725737 BrP-LPA Antagonist / Unkown
HY-148291 BrP-LPA sodium Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lpar1 NCBI NCBI:1902