2. Gene
  3. Grb10 - growth factor receptor bound protein 10 Gene

Grb10 - growth factor receptor bound protein 10 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Meg1; mKIAA0207; 5730571D09Rik

Gene ID: 14783 | Gene type: protein coding

About Grb10

Summary

Enables Insulin Receptor binding activity and signaling receptor complex adaptor activity. Involved in several processes, including negative regulation of glucose import; negative regulation of signal transduction; and positive regulation of cold-induced thermogenesis. Acts upstream of or within with a negative effect on ERK1 and ERK2 cascade and gene expression. Acts upstream of or within insulin-like growth factor receptor signaling pathway and vascular associated smooth muscle cell migration. Predicted to be located in cytosol. Predicted to be part of protein-containing complex. Is expressed in several structures, including branchial arch; extraembryonic component; genitourinary system; sensory organ; and ventricular layer. Orthologous to human GRB10 (growth factor receptor bound protein 10). [provided by Alliance of Genome Resources, Apr 2022]

Grb10 Products(3)

mRNA Protein Name
NM_001177629.1 NP_001171100.1 growth factor receptor-bound protein 10 isoform 2
NM_001370603.1 NP_001357532.1 growth factor receptor-bound protein 10 isoform 3
NM_010345.4 NP_034475.2 growth factor receptor-bound protein 10 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables insulin receptor binding IPI
IPI: Inferred from physical interaction
15664450 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
8621530 MGI
enables protein-macromolecule adaptor activity IDA
IDA: Inferred from direct assay
9062339 MGI
enables signaling receptor complex adaptor activity IPI
IPI: Inferred from physical interaction
15664450 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within negative effect ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
26941017 MGI
acts upstream of or within negative effect gene expression IMP
IMP: Inferred from mutant phenotype
26941017 MGI
acts upstream of or within insulin-like growth factor receptor signaling pathway IPI
IPI: Inferred from physical interaction
12771153 MGI
involved in negative regulation of D-glucose import IMP
IMP: Inferred from mutant phenotype
15664450 MGI
involved in negative regulation of Wnt signaling pathway IDA
IDA: Inferred from direct assay
17376403 MGI
involved in negative regulation of insulin receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
15664450 MGI
involved in negative regulation of phosphorylation IDA
IDA: Inferred from direct assay
15664450 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
24746805 MGI
acts upstream of or within vascular associated smooth muscle cell migration IMP
IMP: Inferred from mutant phenotype
26941017 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

growth factor receptor-bound protein 10

GRB10 adapter protein

maternally expressed gene 1 protein

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05778 GRB10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22539 Grb10 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29059 Grb10 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Grb10 NCBI NCBI:2887