Gria2 - glutamate receptor, ionotropic, AMPA2 (alpha 2) Gene

Also Known as GluA2; Glur2; GluR-B; Glur-2; gluR-K2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14800

Summary

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, Gria1-4. The subunit encoded by this gene (Gria2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to CA(2+). Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008]

Gria2 Products (5)

mRNA Protein Name
NM_001039195.3 NP_001034284.2 glutamate receptor 2 isoform 3 precursor
NM_001083806.3 NP_001077275.2 glutamate receptor 2 isoform 1 precursor
NM_001357924.2 NP_001344853.2 glutamate receptor 2 isoform 4 precursor
NM_001357927.2 NP_001344856.2 glutamate receptor 2 isoform 5 precursor
NM_013540.4 NP_038568.3 glutamate receptor 2 isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables extracellularly glutamate-gated ion channel activity IDA
IDA: Inferred from direct assay
14687553 MGI
enables glutamate-gated receptor activity IDA
IDA: Inferred from direct assay
14687553 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12458226 MGI
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IDA
IDA: Inferred from direct assay
29230056 MGI
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IMP
IMP: Inferred from mutant phenotype
29230056 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within chemical synaptic transmission IDA
IDA: Inferred from direct assay
14687553 MGI
Cellular Component GO Annotation Evidence References Source
part of AMPA glutamate receptor complex IDA
IDA: Inferred from direct assay
15883194 MGI
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
29230056 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
29230056 MGI
located in dendrite IDA
IDA: Inferred from direct assay
29490264 MGI
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
16814779 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
14555717 MGI
located in membrane IDA
IDA: Inferred from direct assay
14687553 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
21558424 MGI
located in perisynaptic space IDA
IDA: Inferred from direct assay
29490264 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
29276473 MGI
located in postsynaptic density IDA
IDA: Inferred from direct assay
15601948 MGI
is active in postsynaptic density membrane IDA
IDA: Inferred from direct assay
14555717 MGI
located in postsynaptic density membrane IDA
IDA: Inferred from direct assay
29490264 MGI
located in postsynaptic membrane IDA
IDA: Inferred from direct assay
19063943 MGI
located in somatodendritic compartment IDA
IDA: Inferred from direct assay
18341993 MGI
located in synapse IDA
IDA: Inferred from direct assay
22632720 MGI
located in synaptic membrane IDA
IDA: Inferred from direct assay
25218043 MGI
located in synaptic vesicle IDA
IDA: Inferred from direct assay
20418887 MGI
located in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
29490264 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glutamate receptor 2

  • AMPA selective glutamate receptor

  • AMPA-selective glutamate receptor 2

  • glutamate receptor B

  • glutamate receptor ionotropic, AMPA 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05792 GRIA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21589 Gria2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28107 Gria2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gria2 NCBI NCBI:2891