GPBAR1 - G protein-coupled bile acid receptor 1 Gene

Also Known as BG37; TGR5; M-BAR; GPCR19; GPR131

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 151306

About GPBAR1

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:218,259,496-218,263,861 (from NCBI)

This gene has 4 transcripts (splice variants) and 75 orthologues. Biased expression in gall bladder (RPKM 4.9), fat (RPKM 2.9) and 11 other tissues.

Summary

This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

GPBAR1 Products (5)

mRNA	Protein	Name
XM_011510743.1	XP_011509045.1	G-protein coupled bile acid receptor 1 isoform X1
NM_001077194.2	NP_001070662.1	G-protein coupled bile acid receptor 1
NM_001077191.2	NP_001070659.1	G-protein coupled bile acid receptor 1
NM_170699.3	NP_733800.1	G-protein coupled bile acid receptor 1
NM_001321950.2	NP_001308879.1	G-protein coupled bile acid receptor 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables G protein-coupled bile acid receptor activity	IDA IDA: Inferred from direct assay	12524422	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	31978385	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway	IDA IDA: Inferred from direct assay	12419312	GOA
involved in cellular response to bile acid	IDA IDA: Inferred from direct assay	12419312	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12524422	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	12419312	GOA
part of receptor complex	IDA IDA: Inferred from direct assay	12419312	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPBAR1 Protein Structure

7tm_1

0
100
200
300
330 a.a.

Protein Preferred Names	Protein Names
G-protein coupled bile acid receptor 1	G-protein coupled bile acid receptor BG37 G-protein coupled receptor GPCR19 membrane bile acid receptor membrane-type receptor for bile acids

Related Diseases

Diseases	Alias
Bile Duct Disease	Bile Duct Diseases Bile Duct Disorder Disorder Of Bile Duct
Functional Diarrhea	Functional Diarrhoea
Diabetes Mellitus	Diabetes
Irritable Bowel Syndrome	Irritable Colon Psychogenic Ibs Ibs - [Irritable Bowel Syndrome] Spastic Bowel Syndrome
Intrahepatic Cholestasis Of Pregnancy	Recurrent Intrahepatic Cholestasis Of Pregnancy Gravidic Intrahepatic Cholestasis Pregnancy-Related Cholestasis Icp Pregnancy Related Cholestasis Cholestasis, Intrahepatic Of Pregnancy Familial Intrahepatic Cholestasis Of Pregnancy Familial Recurrent Intrahepatic Cholestasis Of Pregnancy Ricp Obstetric Cholestasis
Polycystic Liver Disease	Autosomal Dominant Polycystic Liver Disease Isolated Polycystic Liver Disease Pcld Congenital Cystic Liver Disease Congenital Hepatic Cyst Fibrocystic Liver Disease Isolated Autosomal Dominant Polycystic Liver Disease Adpcld Liver Disease, Polycystic Multiple Cysts Of Liver Pld - [Polycystic Liver Disease] Polycystic Liver Disorder Polycystic Liver Congenital Polycystic Disease Of Liver Congenital Polycystic Liver Disease
Ocular Albinism	Albinism, Ocular Oa Xloa Albinism Ocular
Bile Reflux
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Diabetes Mellitus, Non-Insulin-Dependent Type 2 Diabetes T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Sclerosing Cholangitis	Fibrosing Cholangitis Cholangitis, Sclerosing Primary Sclerosing Cholangitis
Choline Deficiency Disease	Choline Deficiency
Cholangitis, Primary Sclerosing	Primary Sclerosing Cholangitis PSC Sclerosing Cholangitis Cholangitis, Sclerosing Cholangitis Primary Sclerosing Psc - [Primary Sclerosing Cholangitis]
Non-Alcoholic Steatohepatitis	Nonalcoholic Steatohepatitis Nash Nash - [Non-Alcoholic Steatohepatitis] Non-Alcoholic Steatohepatosis
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Obesity , Susceptibility To Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Biliary Tract Disease	Biliary Tract Diseases Biliary Tract Abnormality
Cholestasis	Obstruction Of Bile Duct Bile Duct Obstruction Bile Occlusion Extrahepatic Biliary Obstruction Extrahepatic Bile Duct Obstruction Bile Stasis Biliary Stasis Obstructive Hyperbilirubinemia Obstructed Jaundice Bile Duct Obstructed Bile Ductal Obstruction Biliary Duct Obstruction Obstructed Bile Ductal Obstructed Biliary Duct Obstructed Biliary Ductal Jaundice Regurgitation Obstructive Jaundice Cholestatic Jaundice Cholestatic Jaundice Syndrome
Primary Biliary Cholangitis	Primary Biliary Cirrhosis Biliary Liver Cirrhosis Chronic Nonsuppurative Destructive Cholangitis Familial Primary Biliary Cirrhosis Pbc Hanot Syndrome Cholestatic Cirrhosis Biliary Cirrhosis Primary Liver Cirrhosis, Biliary Hanot'S Cirrhosis Biliary Cirrhosis Pericholangiolic Biliary Cirrhosis Tannhauser-Magendantz Syndrome Hanot-Rossle Syndrome Hypertrophic Cirrhosis Todd Cirrhosis Hanot Cirrhosis Charcot Cirrhosis Mahon-Tannhauser Syndrome Toxic Cirrhosis Hypertrophic Biliary Cirrhosis Monolobular Cirrhosis Unilobar Cirrhosis Xanthomatous Biliary Cirrhosis
Cholangitis	Acute Cholangiolitis Ascending Cholangitis Cholangiolitis Cholangitis Nos Chronic Cholangiolitis Hepatic Duct Inflammation Acute Cholangitis Bile Duct Inflammation
Leber Congenital Amaurosis 7	LCA7 Leber Congenital Amaurosis, Type 7

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-101273	BAR502	Agonist	99.53%	Phase 1

Pre-clinical Phase

Bioactive Molecules (18)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-143712	Allolithocholic acid		99.69%	Unkown
HY-101274	BAR501	Agonist	99.95%	Unkown
HY-146453	TGR5 Receptor Agonist 3	Agonist	95.0%	Unkown
HY-147086	CAY10789		99.84%	Unkown
HY-RS05622	GPBAR1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-145234	GPBAR1-IN-3		/	Unkown
HY-107612	GPBAR-A	Agonist	/	Unkown
HY-143712R	Allolithocholic acid (Standard)		/	Unkown
HY-143712S1	Allolithocholic Acid-d4		/	Unkown
HY-168329	TGR5 agonist 7	Agonist	/	Unkown
HY-171949	5β-Cholestane-3α,7α,12α,25-tetrol	Activator	/	Unkown
HY-173466	LT-188A	Agonist	/	Unkown
HY-178477	LIFR/GPBAR1 modulator 1		/	Unkown
HY-RS05623	Gpbar1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05624	Gpbar1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-101274A	(3α,5β,6β,7α)-BAR501		98.0%	Unkown
HY-165155	CysLT1 receptor antagonist-1	Antagonist	/	Unkown
HY-168784	LTD4 antagonist 2	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	GPBAR1	VGNC	VGNC:29521
Macaca mulatta	GPBAR1	VGNC	VGNC:72970
Canis familiaris	GPBAR1	VGNC	VGNC:57385
Mus musculus	GPBAR1	MGD	MGI:2653863
Felis catus	GPBAR1	VGNC	VGNC:80224
Rattus norvegicus	GPBAR1	RGD	RGD:631400
Others	GPBAR1	NCBI