Hint1 - histidine triad nucleotide binding protein 1 Gene

Also Known as Hint; Ipk1; PKCI-1; PRKCNH1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15254

Summary

Predicted to enable adenosine 5'-monophosphoramidase activity. Involved in positive regulation of calcium-mediated signaling and protein desumoylation. Located in nucleus. Is expressed in several structures, including brain; colon; genitourinary system; mammary gland; and spleen. Human ortholog(s) of this gene implicated in Gamstorp-Wohlfart syndrome. Orthologous to human HINT1 (histidine triad nucleotide binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Hint1 Products (1)

mRNA Protein Name
NM_008248.3 NP_032274.1 adenosine 5'-monophosphoramidase HINT1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables deSUMOylase activity IDA
IDA: Inferred from direct assay
31088288 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
31088288 MGI
Biological Process GO Annotation Evidence References Source
involved in positive regulation of calcium-mediated signaling IMP
IMP: Inferred from mutant phenotype
23576580 MGI
involved in protein desumoylation IMP
IMP: Inferred from mutant phenotype
31088288 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
9770345 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

adenosine 5'-monophosphoramidase HINT1

  • PKC inhibitor/ interacting protein

  • adenosine 5'-monophosphoramidase

  • desumoylating isopeptidase HINT1

  • protein kinase C inhibitor 1

  • protein kinase C-interacting protein 1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-113337 Ap4A Inducer / Phase 2

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-113337A Ap4A tetraammonium Inducer 99.98% Unkown
HY-138885 Tryptamine guanosine carbamate Inhibitor 99.79% Unkown
HY-173016 HINT1-IN-1 Modulator / Unkown
HY-RS06176 HINT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21594 Hint1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28112 Hint1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hint1 NCBI NCBI:3094