Hspa8 - heat shock protein 8 Gene

Also Known as Hsc70; Hsc71; Hsc73; Hsp73; Hspa10; 2410008N15Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15481

Summary

Enables ATP hydrolysis activity; phosphatidylserine binding activity; and unfolded protein binding activity. Involved in several processes, including chaperone-mediated protein folding; late endosomal microautophagy; and positive regulation by host of viral genome replication. Acts upstream of or within several processes, including chaperone cofactor-dependent protein refolding; clathrin coat disassembly; and positive regulation of mRNA splicing, via spliceosome. Located in several cellular components, including extracellular exosome; glycinergic synapse; and photoreceptor ribbon synapse. Is active in presynapse. Is expressed in several structures, including 1st branchial arch mandibular component; alimentary system; brain; eye; and forelimb long bone. Human ortholog(s) of this gene implicated in Parkinson's disease and renal hypertension. Orthologous to human HSPA8 (heat shock protein family A (HSP70) member 8). [provided by Alliance of Genome Resources, Apr 2022]

Hspa8 Products (2)

mRNA Protein Name
NM_001364480.1 NP_001351409.1 heat shock cognate 71 kDa protein isoform 2
NM_031165.5 NP_112442.2 heat shock cognate 71 kDa protein isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP hydrolysis activity IDA
IDA: Inferred from direct assay
12588994 MGI
enables phosphatidylserine binding IDA
IDA: Inferred from direct assay
21238931 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12588994 MGI
enables unfolded protein binding IPI
IPI: Inferred from physical interaction
12588994 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within chaperone cofactor-dependent protein refolding IGI
IGI: Inferred from genetic interaction
14644449 MGI
involved in chaperone-mediated protein folding IDA
IDA: Inferred from direct assay
21151134 MGI
involved in chaperone-mediated protein folding IEP
IEP: Inferred from expression pattern
21151134 MGI
involved in chaperone-mediated protein folding IMP
IMP: Inferred from mutant phenotype
21151134 MGI
involved in clathrin coat disassembly IDA
IDA: Inferred from direct assay
8524399 MGI
acts upstream of or within clathrin coat disassembly IGI
IGI: Inferred from genetic interaction
20160091 MGI
involved in late endosomal microautophagy IMP
IMP: Inferred from mutant phenotype
21238931 MGI
involved in modulation by host of viral process IMP
IMP: Inferred from mutant phenotype
26581985 MGI
involved in positive regulation by host of viral genome replication IMP
IMP: Inferred from mutant phenotype
26581985 MGI
acts upstream of or within positive regulation of mRNA splicing, via spliceosome IMP
IMP: Inferred from mutant phenotype
23636947 MGI
acts upstream of or within protein folding IDA
IDA: Inferred from direct assay
12588994 MGI
acts upstream of or within regulation of cell cycle IDA
IDA: Inferred from direct assay
12588994 MGI
involved in regulation of postsynapse organization EXP
EXP: Inferred from Experiment
28234934 MGI
involved in regulation of postsynapse organization IDA
IDA: Inferred from direct assay
28234934 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
26581985 MGI
located in cytosol IDA
IDA: Inferred from direct assay
16906134 MGI
located in extracellular exosome IDA
IDA: Inferred from direct assay
19724054 MGI
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
28234934 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
21209184 MGI
is active in glycinergic synapse IDA
IDA: Inferred from direct assay
21209184 MGI
located in intracellular anatomical structure IDA
IDA: Inferred from direct assay
9122205 MGI
located in late endosome IDA
IDA: Inferred from direct assay
21238931 MGI
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
14627652 MGI
is active in photoreceptor ribbon synapse IDA
IDA: Inferred from direct assay
24616664 MGI
is active in postsynaptic specialization membrane IDA
IDA: Inferred from direct assay
21209184 MGI
is active in presynapse IDA
IDA: Inferred from direct assay
21151134 MGI
is active in presynapse IEP
IEP: Inferred from expression pattern
21151134 MGI
is active in presynapse IMP
IMP: Inferred from mutant phenotype
21151134 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

heat shock cognate 71 kDa protein

  • heat shock 70 kDa protein 8

  • heat shock cognate hsc73

  • heat shock protein cognate 70

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-111002 Displurigen Inhibitor 98.48% Unkown
HY-RS06436 HSPA8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17202 Hspa8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23654 Hspa8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hspa8 NCBI NCBI:3312