Hsf1 - heat shock factor 1 Gene

Also Known as HSTF; HSTF 1; Hsf1beta; Hsf1alpha

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15499

About Hsf1

Chromosome 15: 76,361,622-76,386,113 forward strand.GRCm39:CM001008.3

This gene has 16 transcripts (splice variants), 178 orthologues, 5 paralogues and is associated with 35 phenotypes. Ubiquitous expression in ovary adult (RPKM 47.3), thymus adult (RPKM 42.2) and 28 other tissues.

Summary

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and chromatin binding activity. Involved in positive regulation of cold-induced thermogenesis and positive regulation of gene expression. Acts upstream of or within several processes, including embryo development; gamete generation; and negative regulation of tumor necrosis factor production. Located in cytoplasm and pronucleus. Part of protein-containing complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and immune system. Human ortholog(s) of this gene implicated in Huntington's disease. Orthologous to human HSF1 (heat shock transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Hsf1 Products (5)

mRNA Protein Name
NM_001331153.1 NP_001318082.1 heat shock factor protein 1 isoform gammabeta
NM_008296.3 NP_032322.1 heat shock factor protein 1 isoform beta
NM_001331154.1 NP_001318083.1 heat shock factor protein 1 isoform alpha
NM_001331152.1 NP_001318081.1 heat shock factor protein 1 isoform gammaalpha
NM_001331214.1 NP_001318143.1 heat shock factor protein 1 isoform 5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
11032181 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
18434628 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
21690297 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
18755693 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of cell population proliferation IGI
IGI: Inferred from genetic interaction
15483628 MGI
acts upstream of or within embryonic placenta development IMP
IMP: Inferred from mutant phenotype
10545106 MGI
acts upstream of or within embryonic process involved in female pregnancy IMP
IMP: Inferred from mutant phenotype
10545106 MGI
acts upstream of epithelial cell proliferation IGI
IGI: Inferred from genetic interaction
15483628 MGI
acts upstream of or within female meiotic nuclear division IMP
IMP: Inferred from mutant phenotype
21690297 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
10545106 MGI
acts upstream of or within negative regulation of epithelial cell proliferation IGI
IGI: Inferred from genetic interaction
15483628 MGI
acts upstream of or within negative regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
10545106 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
26344102 MGI
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
26251235 MGI
acts upstream of or within positive regulation of multicellular organism growth IMP
IMP: Inferred from mutant phenotype
10545106 MGI
acts upstream of or within protein phosphorylation IDA
IDA: Inferred from direct assay
18755693 MGI
acts upstream of or within regulation of spindle checkpoint IMP
IMP: Inferred from mutant phenotype
21690297 MGI
acts upstream of or within response to heat IMP
IMP: Inferred from mutant phenotype
10545106 MGI
acts upstream of or within response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
10545106 MGI
acts upstream of or within spermatogenesis IGI
IGI: Inferred from genetic interaction
14994269 MGI
acts upstream of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
10545106 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11032181 MGI
located in nucleus IDA
IDA: Inferred from direct assay
11032181 MGI
located in pronucleus IDA
IDA: Inferred from direct assay
14766729 MGI
part of protein-containing complex IPI
IPI: Inferred from physical interaction
17785525 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Hsf1 Protein Structure

HSF

HSF: smart00415 (13 - 117)

Vert_HS_TF

Vert_HS_TF: pfam06546 (257 - 524)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 525 a.a.
Protein Preferred Names Protein Names

heat shock factor protein 1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-145927 NXP800 Inhibitor 99.86% Phase 1

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-19356 Rocaglamide Inhibitor 99.34% Unkown
HY-103000 HSF1A Activator 99.94% Unkown
HY-100872 KRIBB11 Inhibitor 99.69% Unkown
HY-149127 Rosolutamide Activator 99.03% Unkown
HY-W224634 HSF1-IN-2 Inhibitor / Unkown
HY-N17756 Withanolide D / Unkown
HY-184309 HSF1-IN-3 Inhibitor / Unkown
HY-164184 Ly101-4B Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hsf1 NCBI NCBI:3297