2. Gene
  3. Hsf1 - heat shock factor 1 Gene

Hsf1 - heat shock factor 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as HSTF; HSTF 1; Hsf1beta; Hsf1alpha

Gene ID: 15499 | Gene type: protein coding

About Hsf1

Chromosome 15: 76,361,622-76,386,113 forward strand.GRCm39:CM001008.3

This gene has 16 transcripts (splice variants), 178 orthologues, 5 paralogues and is associated with 35 phenotypes. Ubiquitous expression in ovary adult (RPKM 47.3), thymus adult (RPKM 42.2) and 28 other tissues.

Summary

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and chromatin binding activity. Involved in positive regulation of cold-induced thermogenesis and positive regulation of gene expression. Acts upstream of or within several processes, including embryo development; gamete generation; and negative regulation of tumor necrosis factor production. Located in cytoplasm and pronucleus. Part of protein-containing complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and immune system. Human ortholog(s) of this gene implicated in Huntington's disease. Orthologous to human HSF1 (heat shock transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Hsf1 Products(5)

mRNA Protein Name
NM_001331153.1 NP_001318082.1 heat shock factor protein 1 isoform gammabeta
NM_008296.3 NP_032322.1 heat shock factor protein 1 isoform beta
NM_001331154.1 NP_001318083.1 heat shock factor protein 1 isoform alpha
NM_001331152.1 NP_001318081.1 heat shock factor protein 1 isoform gammaalpha
NM_001331214.1 NP_001318143.1 heat shock factor protein 1 isoform 5

Hsf1 Protein Structure

HSF

HSF: smart00415 (13 - 117)

Vert_HS_TF

Vert_HS_TF: pfam06546 (257 - 524)

  • 0
  • 100
  • 200
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  • 400
  • 525 a.a.
Protein Preferred Names Protein Names

heat shock factor protein 1

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-145927 NXP800 Inhibitor 99.79% Phase 1
Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-19356 Rocaglamide Inhibitor 99.34% Unkown
HY-100872 KRIBB11 Inhibitor 99.54% Unkown
HY-103000 HSF1A Activator 99.46% Unkown
HY-N0754 Eupalinolide A Activator 99.92% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hsf1 NCBI NCBI:3297