HSF1 - heat shock transcription factor 1 Gene

Also Known as HSTF1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3297

About HSF1

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:144,291,604-144,314,720 (from NCBI)

This gene has 14 transcripts (splice variants), 1 gene allele, 178 orthologues and 9 paralogues. Ubiquitous expression in testis (RPKM 49.6), heart (RPKM 24.2) and 25 other tissues.

Summary

The product of this gene is a transcription factor that is rapidly induced after temperature stress and binds heat shock promoter elements (HSE). This protein plays a role in the regulation of lifespan. Expression of this gene is repressed by phosphorylation, which promotes binding by heat shock protein 90. [provided by RefSeq, Jul 2017]

HSF1 Products (10)

mRNA	Protein	Name
XM_047421740.1	XP_047277696.1	heat shock factor protein 1 isoform X4
NM_005526.4	NP_005517.1	heat shock factor protein 1
XM_005272317.3	XP_005272374.1	heat shock factor protein 1 isoform X5
XM_011517006.3	XP_011515308.1	heat shock factor protein 1 isoform X7
XM_005272316.4	XP_005272373.1	heat shock factor protein 1 isoform X2
XM_047421741.1	XP_047277697.1	heat shock factor protein 1 isoform X4
XM_047421742.1	XP_047277698.1	heat shock factor protein 1 isoform X5
XM_017013377.3	XP_016868866.1	heat shock factor protein 1 isoform X3
XM_047421743.1	XP_047277699.1	heat shock factor protein 1 isoform X6
XM_005272315.4	XP_005272372.1	heat shock factor protein 1 isoform X1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	7935471	GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	7760831	GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	24504023	GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	8926278	GOA
enables Hsp90 protein binding	IDA IDA: Inferred from direct assay	11583998	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	8926278	GOA
enables RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	10561509	GOA
enables chromatin DNA binding	IDA IDA: Inferred from direct assay	21085490	GOA
enables general transcription initiation factor binding	IPI IPI: Inferred from physical interaction	11005381	GOA
enables heat shock protein binding	IDA IDA: Inferred from direct assay	9727490	GOA
enables identical protein binding	IDA IDA: Inferred from direct assay	7935471	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	26727490	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9222587	GOA
enables protein heterodimerization activity	IDA IDA: Inferred from direct assay	9222587	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	16278218	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	25963659	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	24504023	GOA
enables translation elongation factor binding	IDA IDA: Inferred from direct assay	16554823	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in MAPK cascade	IDA IDA: Inferred from direct assay	12917326	GOA
involved in cellular response to cadmium ion	IDA IDA: Inferred from direct assay	10359787	GOA
involved in cellular response to copper ion	IDA IDA: Inferred from direct assay	15016915	GOA
involved in cellular response to diamide	IDA IDA: Inferred from direct assay	15016915	GOA
involved in cellular response to gamma radiation	IDA IDA: Inferred from direct assay	26359349	GOA
involved in cellular response to heat	IDA IDA: Inferred from direct assay	7760831	GOA
involved in cellular response to heat	IMP IMP: Inferred from mutant phenotype	8455624	GOA
involved in cellular response to sodium arsenite	IDA IDA: Inferred from direct assay	15016915	GOA
involved in cellular response to unfolded protein	IDA IDA: Inferred from direct assay	15016915	GOA
involved in negative regulation of double-strand break repair via nonhomologous end joining	IMP IMP: Inferred from mutant phenotype	26359349	GOA
involved in negative regulation of protein-containing complex assembly	IMP IMP: Inferred from mutant phenotype	26359349	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	8926278	GOA
involved in positive regulation of DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	24504023	GOA
involved in positive regulation of macrophage differentiation	IMP IMP: Inferred from mutant phenotype	24504023	GOA
involved in positive regulation of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	18794143	GOA
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10561509	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9341107	GOA
involved in protein-containing complex assembly	IDA IDA: Inferred from direct assay	11583998	GOA
involved in regulation of cellular response to heat	IDA IDA: Inferred from direct assay	11583998	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	7760831	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in PML body	IDA IDA: Inferred from direct assay	11514557	GOA
located in centrosome	IDA IDA: Inferred from direct assay	18794143	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	8455624	GOA
located in kinetochore	IDA IDA: Inferred from direct assay	18794143	GOA
located in mitotic spindle pole	IDA IDA: Inferred from direct assay	18794143	GOA
located in nuclear stress granule	IDA IDA: Inferred from direct assay	10359787	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	10359787	GOA
located in nucleus	IDA IDA: Inferred from direct assay	8455624	GOA
located in nucleus	IMP IMP: Inferred from mutant phenotype	26359349	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	21085490	GOA
part of protein folding chaperone complex	IDA IDA: Inferred from direct assay	8455624	GOA
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	16554823	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HSF1 Protein Structure

HSF_DNA-bind

Vert_HS_TF

0
100
200
300
400
500
529 a.a.

Protein Preferred Names	Protein Names
heat shock factor protein 1

HSF1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	HSF1	Q00613	IER5	Homo sapiens	Q5VY09	Pull Down	25816751
Intra	HSF1	Q00613	MINK1	Homo sapiens	Q8N4C8	Pull Down	25816751
Intra	HSF1	Q00613	TMEM185A	Homo sapiens	Q8NFB2	Validated Y2H	32814053
Intra	HSF1	Q00613	TMEM185A	Homo sapiens	Q8NFB2	Y2H Pooling	32814053
Intra	HSF1	Q00613	TMEM185A	Homo sapiens	Q8NFB2	Y2H Array	32814053
Intra	HSF1	Q00613	HSF2	Homo sapiens	Q03933	Pull Down	26727490
Intra	HSF1	Q00613	HSF2	Homo sapiens	Q03933	GMS	26727490
Intra	HSF1	Q00613	HSF2	Homo sapiens	Q03933	Anti Tag CoIP	35271311
Intra	HSF1	Q00613	HSF2	Homo sapiens	Q03933	Anti Tag CoIP	25036637
Intra	HSF1	Q00613	HSF2	Homo sapiens	Q03933	Anti Tag CoIP	26727490
Intra	HSF1	Q00613	HSF2	Homo sapiens	Q03933	Crosslink	26727490
Intra	HSF1	Q00613	KLF15	Homo sapiens	Q9UIH9	Validated Y2H	32814053
Intra	HSF1	Q00613	KLF15	Homo sapiens	Q9UIH9	Y2H Array	32814053
Intra	HSF1	Q00613	KLF15	Homo sapiens	Q9UIH9	Y2H Pooling	32814053
Intra	HSF1	Q00613	PRMT5	Homo sapiens	O14744	Validated Y2H	32814053
Intra	HSF1	Q00613	PRMT5	Homo sapiens	O14744	Y2H Pooling	32814053
Intra	HSF1	Q00613	PRMT5	Homo sapiens	O14744	Y2H Array	32814053
Intra	HSF1	Q00613	PRKCQ	Homo sapiens	Q04759	Protein Kinase Assay	23352416
Intra	HSF1	Q00613	LPIN1	Homo sapiens	Q14693	Y2H Pooling	32814053
Intra	HSF1	Q00613	LPIN1	Homo sapiens	Q14693	Validated Y2H	32814053
Intra	HSF1	Q00613	LPIN1	Homo sapiens	Q14693	Y2H Array	32814053
Intra	HSF1	Q00613	ITGB3BP	Homo sapiens	Q13352	Validated Y2H	32814053
Intra	HSF1	Q00613	ITGB3BP	Homo sapiens	Q13352	Y2H Array	32814053
Intra	HSF1	Q00613	ITGB3BP	Homo sapiens	Q13352	Y2H Pooling	32814053
Intra	HSF1	Q00613	KPNA3	Homo sapiens	O00505	TAP	27173435
Intra	HSF1	Q00613	BAG3	Homo sapiens	O95817	Anti Tag CoIP	25036637
Intra	HSF1	Q00613	BAG3	Homo sapiens	O95817	TAP	27173435
Intra	HSF1	Q00613	HSPBP1	Homo sapiens	Q9NZL4	Anti Tag CoIP	25036637
Intra	HSF1	Q00613	KPNA3	Homo sapiens	O00505	Anti Tag CoIP	25036637
Intra	HSF1	Q00613	HSPBP1	Homo sapiens	Q9NZL4	TAP	27173435
Intra	HSF1	Q00613	MAPKAPK2	Homo sapiens	P49137	Anti Tag CoIP	16278218
Intra	HSF1	Q00613	KPNA4	Homo sapiens	O00629	TAP	27173435
Intra	HSF1	Q00613	KPNA4	Homo sapiens	O00629	Anti Tag CoIP	25036637
Intra	HSF1	Q00613	ZNF232	Homo sapiens	Q9UNY5	Validated Y2H	32814053
Intra	HSF1	Q00613	ZNF232	Homo sapiens	Q9UNY5	Y2H Array	32814053
Intra	HSF1	Q00613	ZNF232	Homo sapiens	Q9UNY5	Y2H Pooling	32814053
Intra	HSF1	Q00613	RPUSD4	Homo sapiens	Q96CM3	Validated Y2H	32814053
Intra	HSF1	Q00613	RPUSD4	Homo sapiens	Q96CM3	Y2H Array	32814053
Intra	HSF1	Q00613	RPUSD4	Homo sapiens	Q96CM3	Y2H Pooling	32814053
Intra	HSF1	Q00613	MAPKAPK2	Homo sapiens	P49137	Pull Down	16278218

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant HSF1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73918	HSF1 Protein, Human (His)	Q00613-1 (D2-S529)	≥ 90%, as determined by reducing SDS-PAGE.

HSF1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80822	Phospho-HSF1 (Ser303/Ser307) Antibody (YA188)	WB, IHC-P	Human
HY-P80822A	Phospho-HSF1 (Ser303/Ser307) Antibody (YA188)(PBS only)	WB, IHC-P	Human
HY-P81050	Phospho-HSF1 (Ser326) Antibody(YA894)	WB, IHC-P, IP	Human
HY-P81052	HSF1 Antibody (YA896)	WB, IHC-P, ICC/IF, IP, FC	Human
HY-P86671	phospho-HSF1 (Ser326) Antibody (YA6363)	WB, IHC-P, IHC-F, ICC/IF, FC	Human, Mouse
HY-P86671A	phospho-HSF1 (Ser326) Antibody (YA6363)(PBS only)	WB, IHC-P, IHC-F, ICC/IF, FC	Human, Mouse

Related Diseases

Diseases	Alias
Hermansky-Pudlak Syndrome 5	HPS5 Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Delta Storage Pool Disease Hermansky-Pudlak Syndrome, Type 5 Platelet Storage Pool Deficiency Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Heat-Shock Rna 1	Hsr1
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Protection Against Lung Cancer, Susceptibility To Adenocarcinoma Of Lung, Somatic Nonsmall Cell Lung Cancer Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-145927	NXP800	Inhibitor	99.86%	Phase 1

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19356	Rocaglamide	Inhibitor	99.34%	Unkown
HY-103000	HSF1A	Activator	99.94%	Unkown
HY-100872	KRIBB11	Inhibitor	99.69%	Unkown
HY-149127	Rosolutamide	Activator	99.03%	Unkown
HY-W224634	HSF1-IN-2	Inhibitor	/	Unkown
HY-N17756	Withanolide D		/	Unkown
HY-184309	HSF1-IN-3	Inhibitor	/	Unkown
HY-164184	Ly101-4B	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	HSF1	VGNC	VGNC:41814
Rattus norvegicus	HSF1	RGD	RGD:620913
Bos taurus	HSF1	VGNC	VGNC:29981
Felis catus	HSF1	VGNC	VGNC:67661
Mus musculus	HSF1	MGD	MGI:96238
Macaca mulatta	HSF1	VGNC	VGNC:73531
Others	HSF1	NCBI