CDCA2 - cell division cycle associated 2 Gene

Also Known as PPP1R81; Repo-Man

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 157313

About CDCA2

Cytogenetic location: 8p21.2 Genomic coordinates (GRCh38): 8:25,458,931-25,507,917 (from NCBI)

This gene has 5 transcripts (splice variants), 184 orthologues and 1 paralogue. Biased expression in testis (RPKM 7.7), lymph node (RPKM 1.9) and 9 other tissues.

Summary

This gene encodes a targeting subunit of the cell-cycle associated protein, protein Phosphatase 1, with a role in targeting this protein to chromatin during anaphase. These two proteins comprise a Phosphatase complex that is involved in nuclear envelope reformation and regulation of the DNA damage response. The encoded protein may also play a role in Cancer progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

CDCA2 Products (3)

mRNA Protein Name
NM_001317906.1 NP_001304835.1 cell division cycle-associated protein 2 isoform 2
NM_001317907.1 NP_001304836.1 cell division cycle-associated protein 2 isoform 3
NM_152562.4 NP_689775.2 cell division cycle-associated protein 2 isoform 1

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
located in chromosome IDA
IDA: Inferred from direct assay
22801782 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDCA2 Protein Structure

PP1_bind

PP1_bind: Protein phosphatase 1 binding (388 - 450)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1023 a.a.
Protein Preferred Names Protein Names

cell division cycle-associated protein 2

  • protein phosphatase 1, regulatory subunit 81

Related Diseases

Diseases Alias
Uterine Adnexa Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02311 CDCA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21511 Cdca2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28029 Cdca2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CDCA2 VGNC VGNC:60666
Macaca mulatta CDCA2 VGNC VGNC:70710
Rattus norvegicus CDCA2 RGD RGD:1311003
Bos taurus CDCA2 VGNC VGNC:59194
Canis familiaris CDCA2 VGNC VGNC:39012
Mus musculus CDCA2 MGD MGI:1919787
Others CDCA2 NCBI