Cd79b - CD79B antigen Gene

Also Known as B29; Igb; Igbeta; Ig-beta

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15985

Summary

The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two Other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Sep 2015]

Cd79b Products (2)

mRNA Protein Name
NM_001313939.1 NP_001300868.1 B-cell antigen receptor complex-associated protein beta chain isoform 2 precursor
NM_008339.3 NP_032365.1 B-cell antigen receptor complex-associated protein beta chain isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
20696394 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
1373499 MGI
enables transmembrane signaling receptor activity IDA
IDA: Inferred from direct assay
8626447 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within B cell receptor signaling pathway IDA
IDA: Inferred from direct assay
1373499 MGI
involved in B cell receptor signaling pathway IDA
IDA: Inferred from direct assay
8626447 MGI
acts upstream of or within response to bacterium IEP
IEP: Inferred from expression pattern
23012479 MGI
Cellular Component GO Annotation Evidence References Source
part of B cell receptor complex IDA
IDA: Inferred from direct assay
1373499 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
1373499 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

B-cell antigen receptor complex-associated protein beta chain

  • B-cell-specific glycoprotein B29

  • immunoglobulin-associated B29 protein

  • immunoglobulin-associated beta

Cd79b Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Cd79b P15530 Cd79b Mus musculus P15530
Comigration in SDS
20696394
Intra
Cd79b P15530 Cd79b Mus musculus P15530
X-Ray Diffraction
20696394
Intra
Cd79b P15530 Cd79b Mus musculus P15530
GMS
20696394
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Cd79b Proteins

Cat. No. Product Name Accession Purity
HY-P72707 CD79B Protein, Mouse (HEK293, Fc) P15530 (V26-D158) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P75385 CD79 Protein, Mouse (HEK293, His) P11911 (L29-R137)&P15530 (V26-D158) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78263 CD79B Protein, Mouse (HEK293, His) P15530 (V26-D158) ≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-132253 Polatuzumab vedotin Inhibitor 99.37% Unkown

Clinical Phase

Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99042 Polatuzumab 99.69% Phase 3
HY-P991671 Anafiltamig Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-132253A Polatuzumab vedotin (solution) Inhibitor 99.40% Unkown
HY-163295 BTK degrader-1 Degrader 99.40% Unkown
HY-157763 Mal-PEG1-Val-Cit-PABC-diphosphate-BTK degrader-1 Degrader / Unkown
HY-P11779 Ac-RKAA-PABC-MMAE Inhibitor / Unkown
HY-RS02268 CD79B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17825 Cd79b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24293 Cd79b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99656 Iladatuzumab 96.97% Unkown
HY-P991086 MGD010 Inhibitor 99.06% Unkown
HY-P991804 Anti-Mouse CD79b Antibody (HM79b) Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cd79b NCBI NCBI:974