Igf2r - insulin-like growth factor 2 receptor Gene

Also Known as CD222; CI-MPR; Mpr300; M6P/IGF2R

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16004

Summary

Enables insulin-like growth factor binding activity and mannose binding activity. Predicted to be involved in several processes, including liver development; positive regulation by host of viral process; and response to retinoic acid. Located in membrane and nuclear envelope lumen. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; early conceptus; and genitourinary system. Human ortholog(s) of this gene implicated in diabetes mellitus (multiple); hepatocellular carcinoma; in situ carcinoma (multiple); and nephroblastoma. Orthologous to human IGF2R (Insulin like growth factor 2 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Igf2r Products (1)

mRNA Protein Name
NM_010515.2 NP_034645.2 cation-independent mannose-6-phosphate receptor precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables D-mannose binding IDA
IDA: Inferred from direct assay
2963825 MGI
enables insulin-like growth factor binding IPI
IPI: Inferred from physical interaction
14566968 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
2963825 MGI
Cellular Component GO Annotation Evidence References Source
located in membrane IDA
IDA: Inferred from direct assay
2963825 MGI
located in nuclear envelope lumen IDA
IDA: Inferred from direct assay
12729502 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12729502 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cation-independent mannose-6-phosphate receptor

  • 300 kDa mannose 6-phosphate receptor

  • CI Man-6-P receptor

  • IGF-II receptor

  • IGF-II/CI-MPR

  • M6P/IGF2 receptor

  • M6PR

  • MPR 300

  • cation-independent MPR

  • insulin-like growth factor II receptor

  • mannose-6-phosphate receptor, cation independent

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06622 IGF2R Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-E70730 INSR Recombinant Human Active Protein Kinase / Unkown
HY-RS17981 Igf2r Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24452 Igf2r Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Igf2r NCBI NCBI:3482