Il18rap - interleukin 18 receptor accessory protein Gene

Also Known as AcPL; IL-18RAcP; IL-1RAcPL; IL-18Rbeta; IL-18R-beta

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16174

Summary

Interleukin-18 (or interferon-gamma inducing factor) is a proinflammatory cytokine that induces cell-mediated immunity following microbial Infection. This gene encodes a member of the interleukin-1 receptor family. The encoded protein is an accessory subunit of the receptor for interleukin-18 and mediates signaling through this cytokine. Mice lacking this gene exhibit a defective cell-mediated immune response. [provided by RefSeq, Jan 2014]

Il18rap Products (1)

mRNA Protein Name
NM_010553.4 NP_034683.1 interleukin-18 receptor accessory protein precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within T-helper 1 cell cytokine production IMP
IMP: Inferred from mutant phenotype
15843532 MGI
acts upstream of or within cell population proliferation IMP
IMP: Inferred from mutant phenotype
15843532 MGI
acts upstream of or within cellular response to interleukin-18 IMP
IMP: Inferred from mutant phenotype
15843532 MGI
acts upstream of or within interleukin-18-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
15843532 MGI
acts upstream of or within interleukin-6 production IMP
IMP: Inferred from mutant phenotype
15843532 MGI
acts upstream of or within neutrophil activation IMP
IMP: Inferred from mutant phenotype
15843532 MGI
acts upstream of or within positive regulation of natural killer cell mediated cytotoxicity IMP
IMP: Inferred from mutant phenotype
15843532 MGI
acts upstream of or within type II interferon production IMP
IMP: Inferred from mutant phenotype
15843532 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interleukin-18 receptor accessory protein

  • AcPL accessory protein-like)

  • CD218 antigen-like family member B

  • IL-18 receptor accessory protein

  • accessory protein-like

  • interleukin-18 receptor beta

Recombinant Il18rap Proteins

Cat. No. Product Name Accession Purity
HY-P75848 IL-18RAP Protein, Mouse (sf9, His) Q9Z2B1 (F20-E356) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78316 IL-18RAP Protein, Mouse (HEK293, His) Q9Z2B1 (F20-E356) ≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06711 IL18RAP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20633 Il18rap Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27142 Il18rap Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992238 Anti-IL-18RAP Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il18rap NCBI NCBI:8807