DEDD2 - death effector domain containing 2 Gene

Also Known as FLAME3; FLAME-3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 162989

About DEDD2

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:42,198,598-42,220,134 (from NCBI)

This gene has 13 transcripts (splice variants), 188 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 24.8), spleen (RPKM 9.9) and 25 other tissues.

Summary

This gene encodes a nuclear-localized protein containing a death effector domain (DED). The encoded protein may regulate the trafficking of caspases and Other proteins into the nucleus during death receptor-induced Apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

DEDD2 Products (3)

mRNA Protein Name
NM_001270614.2 NP_001257543.1 DNA-binding death effector domain-containing protein 2 isoform 1
NM_001270615.2 NP_001257544.1 DNA-binding death effector domain-containing protein 2 isoform 2
NM_133328.4 NP_579874.1 DNA-binding death effector domain-containing protein 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11741985 GOA
Biological Process GO Annotation Evidence References Source
involved in apoptotic nuclear changes IDA
IDA: Inferred from direct assay
11741985 GOA
involved in extrinsic apoptotic signaling pathway via death domain receptors IMP
IMP: Inferred from mutant phenotype
11741985 GOA
involved in positive regulation of extrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
11741985 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleolus IDA
IDA: Inferred from direct assay
11741985 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DEDD2 Protein Structure

DED

DED: Death effector domain (26 - 109)

  • 0
  • 100
  • 200
  • 300
  • 326 a.a.
Protein Preferred Names Protein Names

DNA-binding death effector domain-containing protein 2

  • DED-containing protein FLAME-3

Related Diseases

Diseases Alias
Leukorrhea

  • Discharge - Leukorrhea

  • Leukorrhea Of Vagina
Colorectal Adenocarcinoma

  • Adenocarcinoma Of Large Intestine
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03670 DEDD2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus DEDD2 MGD MGI:1914629
Bos taurus DEDD2 VGNC VGNC:27985
Felis catus DEDD2 VGNC VGNC:61424
Macaca mulatta DEDD2 VGNC VGNC:109614
Canis familiaris DEDD2 VGNC VGNC:39873
Rattus norvegicus DEDD2 RGD RGD:1588968
Others DEDD2 NCBI