Krt17 - keratin 17 Gene

Also Known as K17; Krt1-17

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16667

Summary

The protein encoded by this gene is a member of the type I keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The encoded protein is a cytokeratin required for the normal growth of hair follicles and may act in psoriasis as an immunopathogenic autoantigen. [provided by RefSeq, Sep 2015]

Krt17 Products (1)

mRNA Protein Name
NM_010663.3 NP_034793.1 keratin, type I cytoskeletal 17

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16702408 MGI
Biological Process GO Annotation Evidence References Source
involved in hair follicle morphogenesis IMP
IMP: Inferred from mutant phenotype
12050118 MGI
acts upstream of or within intermediate filament organization IGI
IGI: Inferred from genetic interaction
15601842 MGI
acts upstream of or within keratinization IGI
IGI: Inferred from genetic interaction
15601842 MGI
acts upstream of or within morphogenesis of an epithelium IGI
IGI: Inferred from genetic interaction
15601842 MGI
involved in positive regulation of cell growth IMP
IMP: Inferred from mutant phenotype
16710422 MGI
involved in positive regulation of hair follicle development IMP
IMP: Inferred from mutant phenotype
16702408 MGI
involved in positive regulation of translation IMP
IMP: Inferred from mutant phenotype
16710422 MGI
Cellular Component GO Annotation Evidence References Source
located in cell periphery IDA
IDA: Inferred from direct assay
16682203 MGI
is active in cornified envelope IDA
IDA: Inferred from direct assay
26644517 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
16702408 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

keratin, type I cytoskeletal 17

  • CK-17

  • cytokeratin-17

  • keratin complex 1, acidic, gene 17

Krt17 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Krt17 Q9QWL7 Sfn Mus musculus O70456
IF
16710422
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07440 KRT17 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18530 Krt17 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25012 Krt17 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Krt17 NCBI NCBI:3872