Krt18 - keratin 18 Gene

Also Known as K18; CK18; Krt1-18

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16668

Summary

Predicted to enable scaffold protein binding activity. Acts upstream of or within extrinsic apoptotic signaling pathway; hepatocyte apoptotic process; and tumor necrosis factor-mediated signaling pathway. Located in cell periphery and keratin filament. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in liver cirrhosis. Orthologous to human KRT18 (keratin 18). [provided by Alliance of Genome Resources, Apr 2022]

Krt18 Products (1)

mRNA Protein Name
NM_010664.2 NP_034794.2 keratin, type I cytoskeletal 18

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10747083 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within extrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
10747083 MGI
acts upstream of or within hepatocyte apoptotic process IMP
IMP: Inferred from mutant phenotype
10747083 MGI
acts upstream of or within tumor necrosis factor-mediated signaling pathway IGI
IGI: Inferred from genetic interaction
10747083 MGI
Cellular Component GO Annotation Evidence References Source
located in cell periphery IDA
IDA: Inferred from direct assay
23284756 MGI
located in intermediate filament IDA
IDA: Inferred from direct assay
10747083 MGI
located in keratin filament IDA
IDA: Inferred from direct assay
21930775 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

keratin, type I cytoskeletal 18

  • cytokeratin endo B

  • cytokeratin-18

  • keratin D

  • keratin complex 1, acidic, gene 18

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07441 KRT18 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19704 Krt18 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26199 Krt18 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Krt18 NCBI NCBI:3875