Lamc2 - laminin, gamma 2 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16782

Summary

Enables heparin binding activity. Predicted to be involved in several processes, including neuron projection development; positive regulation of cell migration; and positive regulation of cell population proliferation. Predicted to act upstream of or within cell adhesion. Located in basement membrane. Part of laminin-5 complex. Is expressed in several structures, including alimentary system; basement membrane; central nervous system; genitourinary system; and skin. Used to study junctional epidermolysis bullosa Herlitz type and junctional epidermolysis bullosa non-Herlitz type. Human ortholog(s) of this gene implicated in junctional epidermolysis bullosa; junctional epidermolysis bullosa Herlitz type; junctional epidermolysis bullosa non-Herlitz type; and lung small cell carcinoma. Orthologous to human LAMC2 (laminin subunit gamma 2). [provided by Alliance of Genome Resources, Apr 2022]

Lamc2 Products (1)

mRNA Protein Name
NM_008485.3 NP_032511.3 laminin subunit gamma-2 precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables heparin binding IDA
IDA: Inferred from direct assay
11733994 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11733994 MGI
Cellular Component GO Annotation Evidence References Source
located in basement membrane IDA
IDA: Inferred from direct assay
9264260 MGI
part of laminin-5 complex IDA
IDA: Inferred from direct assay
9264260 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

laminin subunit gamma-2

  • epiligrin subunit gamma

  • kalinin subunit gamma

  • kalinin/nicein/epiligrin 100 kDa subunit

  • laminin B2t chain

  • laminin gamma2 chain

  • laminin-5 subunit gamma

  • nicein subunit gamma

  • nicein, 100kD

  • nicein, 100kDa

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07507 LAMC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20979 Lamc2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27496 Lamc2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lamc2 NCBI NCBI:3918