Lats1 - large tumor suppressor Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16798

Summary

Predicted to enable several functions, including ATP binding activity; Estrogen receptor binding activity; and magnesium ion binding activity. Involved in hormone-mediated signaling pathway; negative regulation of protein localization to nucleus; and regulation of transforming growth factor beta receptor signaling pathway. Acts upstream of or within several processes, including hippo signaling; inner cell mass cell differentiation; and keratinocyte differentiation. Predicted to be located in cytoplasm and Cytoskeleton. Predicted to be active in spindle pole. Is expressed in acoustic ganglion; early conceptus; embryo; endolymphatic appendage; and otocyst. Orthologous to human LATS1 (large tumor suppressor kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Lats1 Products (1)

mRNA Protein Name
NM_010690.1 NP_034820.1 serine/threonine-protein kinase LATS1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21145499 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within hippo signaling IGI
IGI: Inferred from genetic interaction
18369314 MGI
involved in hormone-mediated signaling pathway IDA
IDA: Inferred from direct assay
9988269 MGI
acts upstream of or within inner cell mass cell fate commitment IGI
IGI: Inferred from genetic interaction
23824537 MGI
acts upstream of or within inner cell mass cellular morphogenesis IGI
IGI: Inferred from genetic interaction
23824537 MGI
acts upstream of or within keratinocyte differentiation IGI
IGI: Inferred from genetic interaction
18369314 MGI
involved in negative regulation of protein localization to nucleus IMP
IMP: Inferred from mutant phenotype
21145499 MGI
acts upstream of or within protein localization IGI
IGI: Inferred from genetic interaction
19289085 MGI
involved in regulation of transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
21145499 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serine/threonine-protein kinase LATS1

  • WARTS protein kinase

  • large tumor suppressor homolog 1

  • large tumor supressor, homolog 1

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14889 Fluciclovine / Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-164401 QBS10072S Inducer / Phase 2
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990610 KHK-2898 Inhibitor 97.16% Phase 1

Pre-clinical Phase

Bioactive Molecules (25)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-138489 TRULI Inhibitor 99.98% Unkown
HY-108540 BCH Inducer 99.83% Unkown
HY-147082 GA-017 98.95% Unkown
HY-W011391 GPNA hydrochloride 99.91% Unkown
HY-W087830 L-p-Boronophenylalanine 99.84% Unkown
HY-120139 KMH-233 Inhibitor 99.75% Unkown
HY-147165 VT02956 Inhibitor 99.58% Unkown
HY-139330 MGH-CP1 Inducer 99.56% Unkown
HY-176886 LATS-IN-2 Inhibitor 99.45% Unkown
HY-164254 Cardiomyocyte proliferation promoting agent-1 Inhibitor 99.87% Unkown
HY-175247 DDO-4033 99.11% Unkown
HY-W267524 H-Phe(3-CF3)-OH / Unkown
HY-120139A (R)-KMH-233 Control / Unkown
HY-183513 L-Ala-BPA Substrate / Unkown
HY-RS07538 LATS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-108540R BCH (Standard) Inducer 99.84% Unkown
HY-147165A VT02956 hydrochloride Inhibitor / Unkown
HY-164401A QBS10072S dihydrochloride / Unkown
HY-175649 LATS1/2-IN-1 Inhibitor / Unkown
HY-181743 Piezo1 agonist 2 Agonist / Unkown
HY-182254 AChE/BChE-IN-35 Inhibitor / Unkown
HY-183147A LAT1-IN-2 hydrochloride Substrate / Unkown
HY-RS17343 Lats1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23797 Lats1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W246010 α,α-DiBn-DL-Gly Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lats1 NCBI NCBI:9113