Lcn2 - lipocalin 2 Gene

Also Known as NRL; 24p3; Sip24

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16819

Summary

Enables iron ion binding activity. Involved in innate immune response; positive regulation of cold-induced thermogenesis; and siderophore transport. Acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand; response to bacterium; and response to virus. Located in extracellular space. Is expressed in several structures, including genitourinary system; gut; liver; lung; and spleen. Human ortholog(s) of this gene implicated in intrahepatic cholangiocarcinoma and urinary tract Infection. Orthologous to human LCN2 (lipocalin 2). [provided by Alliance of Genome Resources, Apr 2022]

Lcn2 Products (1)

mRNA Protein Name
NM_008491.1 NP_032517.1 neutrophil gelatinase-associated lipocalin precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables iron ion binding IDA
IDA: Inferred from direct assay
16377569 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16377569 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand IDA
IDA: Inferred from direct assay
16377569 MGI
involved in innate immune response IMP
IMP: Inferred from mutant phenotype
16446425 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
20332347 MGI
acts upstream of or within response to bacterium IEP
IEP: Inferred from expression pattern
23012479 MGI
acts upstream of or within response to virus IDA
IDA: Inferred from direct assay
2542864 MGI
involved in siderophore transport IDA
IDA: Inferred from direct assay
16377569 MGI
involved in siderophore transport IMP
IMP: Inferred from mutant phenotype
20550936 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular region IDA
IDA: Inferred from direct assay
16377569 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
29402223 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neutrophil gelatinase-associated lipocalin

  • SV-40-induced 24P3 protein

  • neu-related lipocalin

  • oncogene 24p3

  • p25

  • secreted inducible protein 24

  • siderocalin LCN2

Recombinant Lcn2 Proteins

Cat. No. Product Name Accession Purity
HY-P70658 Lipocalin-2/NGAL Protein, Mouse (HEK293, His, solution) P11672 (Q21-N200) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78329 Lipocalin-2/NGAL Protein, Mouse (HEK293, Fc) P11672 (Q21-N200) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P70658A Lipocalin-2/NGAL Protein, Mouse (HEK293, C-His) P11672 (Q21-N200) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-Q45780 ZINC00640089 99.95% Unkown
HY-148364 ZINC00784494 Inhibitor 99.96% Unkown
HY-RS07557 LCN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-164959 ZINC00230567 Inhibitor 99.69% Unkown
HY-RS16572 Lcn2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-132195 RORγt inverse agonist 14 Inhibitor / Unkown
HY-158049 Anticancer agent 199 Inducer / Unkown
HY-RS23005 Lcn2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lcn2 NCBI NCBI:3934