Lif - leukemia inhibitory factor Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16878

Summary

Enables cytokine activity and growth factor activity. Acts upstream of or within several processes, including animal organ development; generation of neurons; and positive regulation of macromolecule metabolic process. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; cranium; early conceptus; and female reproductive system. Orthologous to human LIF (LIF interleukin 6 family cytokine). [provided by Alliance of Genome Resources, Apr 2022]

Lif Products (3)

mRNA Protein Name
NM_001039537.3 NP_001034626.1 leukemia inhibitory factor isoform b
NM_001412335.1 NP_001399264.1 leukemia inhibitory factor isoform a precursor
NM_008501.3 NP_032527.1 leukemia inhibitory factor isoform a precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables cytokine activity IDA
IDA: Inferred from direct assay
1522892 MGI
enables growth factor activity IMP
IMP: Inferred from mutant phenotype
1522892 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within blood vessel remodeling IGI
IGI: Inferred from genetic interaction
16691571 MGI
acts upstream of or within cell morphogenesis IMP
IMP: Inferred from mutant phenotype
18548006 MGI
acts upstream of cell population proliferation IGI
IGI: Inferred from genetic interaction
16691571 MGI
acts upstream of or within decidualization IDA
IDA: Inferred from direct assay
1522892 MGI
acts upstream of or within decidualization IMP
IMP: Inferred from mutant phenotype
1522892 MGI
acts upstream of or within embryo implantation IDA
IDA: Inferred from direct assay
1522892 MGI
acts upstream of or within embryo implantation IMP
IMP: Inferred from mutant phenotype
1522892 MGI
acts upstream of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
1522892 MGI
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
18548006 MGI
acts upstream of or within lung alveolus development IGI
IGI: Inferred from genetic interaction
16691571 MGI
acts upstream of or within lung development IGI
IGI: Inferred from genetic interaction
16691571 MGI
acts upstream of or within lung lobe morphogenesis IGI
IGI: Inferred from genetic interaction
16691571 MGI
acts upstream of or within lung vasculature development IGI
IGI: Inferred from genetic interaction
16691571 MGI
acts upstream of or within maternal process involved in female pregnancy IMP
IMP: Inferred from mutant phenotype
1522892 MGI
acts upstream of meiotic nuclear division IDA
IDA: Inferred from direct assay
11203703 MGI
acts upstream of or within muscle organ morphogenesis IMP
IMP: Inferred from mutant phenotype
15716414 MGI
acts upstream of or within negative regulation of ERK1 and ERK2 cascade IGI
IGI: Inferred from genetic interaction
16691571 MGI
acts upstream of or within negative regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
16691571 MGI
acts upstream of or within negative regulation of meiotic nuclear division IDA
IDA: Inferred from direct assay
11203703 MGI
acts upstream of or within neuron development IGI
IGI: Inferred from genetic interaction
15716414 MGI
acts upstream of or within positive regulation of astrocyte differentiation IDA
IDA: Inferred from direct assay
10486560 MGI
acts upstream of or within positive regulation of fibroblast proliferation IMP
IMP: Inferred from mutant phenotype
1522892 MGI
acts upstream of or within positive regulation of gene expression IGI
IGI: Inferred from genetic interaction
7959007 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
21385842 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
16691571 MGI
acts upstream of or within regulation of RNA polymerase II regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
21385842 MGI
acts upstream of or within regulation of cell differentiation IGI
IGI: Inferred from genetic interaction
16258063 MGI
acts upstream of or within response to hypoxia IMP
IMP: Inferred from mutant phenotype
18548006 MGI
acts upstream of or within somatic stem cell population maintenance IDA
IDA: Inferred from direct assay
15358627 MGI
acts upstream of or within somatic stem cell population maintenance IGI
IGI: Inferred from genetic interaction
15358627 MGI
acts upstream of or within spongiotrophoblast differentiation IGI
IGI: Inferred from genetic interaction
16258063 MGI
acts upstream of or within stem cell differentiation IDA
IDA: Inferred from direct assay
22949634 MGI
acts upstream of or within trophoblast giant cell differentiation IGI
IGI: Inferred from genetic interaction
16258063 MGI
acts upstream of or within tyrosine phosphorylation of STAT protein IDA
IDA: Inferred from direct assay
15012602 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

leukemia inhibitory factor

  • d factor

  • differentiation-stimulating factor

  • myeloid leukaemia inhibitory factor

Recombinant Lif Proteins

Cat. No. Product Name Accession Purity
HY-P7084 LIF Protein, Mouse P09056 (S24-F203) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73279 LIF Protein, Mouse (HEK293) P09056/NP_032527.1 (S24-F203) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73280 LIF Protein, Mouse (HEK293, His) P09056 (S24-F203) ≥ 85%, as determined by reducing SDS-PAGE.
HY-P78324 LIF Protein, Mouse (HEK293, Fc) P09056 (P25-F203) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P700220AF Animal-Free LIF Protein, Mouse (His) P09056 (S24-F203) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990461 Anti-LIF Antibody (MSC-1) Inhibitor 98.51% Phase 1

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-120142 EC359 Inducer 99.77% Unkown
HY-D0974 Sulforhodamine B sodium salt 99.43% Unkown
HY-100949 EC330 Inhibitor 99.90% Unkown
HY-D1603 BODIPY FL-EDA 97.86% Unkown
HY-103471 Y11 Activator 98.34% Unkown
HY-178477 LIFR/GPBAR1 modulator 1 / Unkown
HY-184832 P021 Inhibitor / Unkown
HY-RS07640 LIF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-N16657 Fusaricidin B Inhibitor / Unkown
HY-RS16531 Lif Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17192 Lifr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22962 Lif Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lif NCBI NCBI:3976