Sh2b3 - SH2B adaptor protein 3 Gene

Also Known as Lnk

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16923

Summary

This gene encodes a member of the SH2B family of adapter proteins that play an important role in T cell receptor signaling. This gene is preferentially expressed in hematopoietic stem cells, hematopoietic progenitors, pre and immature B cells, as well as megakaryocytes and mastocytes. In hematopoietic stem cells, the encoded protein is a key regulator of self-renewal, proliferation and Apoptosis. Mice lacking the encoded protein exhibit pre and immature B cell expansion in spleen and the bone marrow. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

Sh2b3 Products (4)

mRNA Protein Name
NM_001306126.2 NP_001293055.1 SH2B adapter protein 3 isoform 1
NM_001306127.2 NP_001293056.1 SH2B adapter protein 3 isoform 1
NM_001306128.2 NP_001293057.1 SH2B adapter protein 3 isoform 2
NM_008507.5 NP_032533.1 SH2B adapter protein 3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11805142 MGI
enables protein tyrosine kinase binding IPI
IPI: Inferred from physical interaction
14612394 MGI
enables signaling receptor complex adaptor activity IPI
IPI: Inferred from physical interaction
14612394 MGI
enables stem cell factor receptor binding IDA
IDA: Inferred from direct assay
14612394 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative effect cellular response to chemokine IMP
IMP: Inferred from mutant phenotype
15337790 MGI
involved in cellular response to interleukin-3 IDA
IDA: Inferred from direct assay
15337790 MGI
acts upstream of or within embryonic hemopoiesis IDA
IDA: Inferred from direct assay
14612394 MGI
acts upstream of negative effect embryonic hemopoiesis IMP
IMP: Inferred from mutant phenotype
14612394 MGI
acts upstream of or within embryonic hemopoiesis IMP
IMP: Inferred from mutant phenotype
14612394 MGI
acts upstream of or within hematopoietic stem cell differentiation IMP
IMP: Inferred from mutant phenotype
14612394 MGI
acts upstream of or within hemopoiesis IMP
IMP: Inferred from mutant phenotype
11805142 MGI
acts upstream of or within intracellular signal transduction IDA
IDA: Inferred from direct assay
11805142 MGI
involved in megakaryocyte development IMP
IMP: Inferred from mutant phenotype
15337790 MGI
involved in monocyte homeostasis IGI
IGI: Inferred from genetic interaction
27430239 MGI
involved in negative regulation of Kit signaling pathway IMP
IMP: Inferred from mutant phenotype
14612394 MGI
involved in negative regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
15337790 MGI
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
15337790 MGI
involved in negative regulation of chemokine-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
15337790 MGI
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: Inferred from direct assay
15337790 MGI
involved in negative regulation of platelet aggregation IGI
IGI: Inferred from genetic interaction
27430239 MGI
involved in negative regulation of receptor signaling pathway via STAT IMP
IMP: Inferred from mutant phenotype
15337790 MGI
involved in neutrophil homeostasis IGI
IGI: Inferred from genetic interaction
27430239 MGI
acts upstream of negative effect thrombopoietin-mediated signaling pathway IGI
IGI: Inferred from genetic interaction
27430239 MGI
involved in thrombopoietin-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
15337790 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

SH2B adapter protein 3

  • linker of T-cell receptor pathways

  • lymphocyte-specific adapter protein Lnk

  • signal transduction protein Lnk

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12820 SH2B3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22804 Sh2b3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29318 Sh2b3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sh2b3 NCBI NCBI:10019