Maf - avian musculoaponeurotic fibrosarcoma oncogene homolog Gene

Also Known as c-maf; 2810401A20Rik; A230108G15Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 17132

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Acts upstream of or within several processes, including regulation of chondrocyte differentiation; regulation of transcription by RNA polymerase II; and sensory organ development. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and lower leg. Used to study cataract 21 multiple types and multiple myeloma. Human ortholog(s) of this gene implicated in Ayme-Gripp syndrome; cataract; and cataract 21 multiple types. Orthologous to human MAF (MAF bZIP transcription factor). [provided by Alliance of Genome Resources, Apr 2022]

Maf Products (1)

mRNA	Protein	Name
NM_001025577.2	NP_001020748.2	transcription factor Maf

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	12381733	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	19414009	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	12835653	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12381733	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	10603348	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cell development	IMP IMP: Inferred from mutant phenotype	10603348	MGI
acts upstream of or within cytokine production	IDA IDA: Inferred from direct assay	15790681	MGI
acts upstream of or within inner ear development	IDA IDA: Inferred from direct assay	21795542	MGI
acts upstream of or within lens development in camera-type eye	IMP IMP: Inferred from mutant phenotype	10383433	MGI
acts upstream of or within lens fiber cell differentiation	IMP IMP: Inferred from mutant phenotype	10383433	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	19623612	MGI
acts upstream of or within positive regulation of gene expression	IDA IDA: Inferred from direct assay	21460847	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12381733	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	10603348	MGI
acts upstream of or within regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	10403649	MGI
acts upstream of or within regulation of chondrocyte differentiation	IMP IMP: Inferred from mutant phenotype	14512017	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15249232	MGI
located in nucleus	IDA IDA: Inferred from direct assay	15249232	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
transcription factor Maf	V-maf musculoaponeurotic fibrosarcoma oncogene homolog avian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog c-Maf long form proto-oncogene c-maf

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-119271	CMLD010509		99.11%	Unkown
HY-W339331	Flubendiamide	Activator	99.42%	Unkown
HY-P11601	MAF-10L		/	Unkown
HY-RS07956	MAF Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS07957	MAF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-119271A	(-)-CMLD010509		/	Unkown
HY-174585	Human MAFA mRNA		/	Unkown
HY-185661	IBS007125	Inhibitor	/	Unkown
HY-RS17799	Maf Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24267	Maf Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27194	Mmd Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99136	Anti-Mouse IFN gamma Antibody (H22)	Inhibitor	95.00%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Maf	NCBI	NCBI:4094