Slc26a6 - solute carrier family 26, member 6 Gene

Also Known as CFEX; Pat1; Pat-1; B930010B04Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 171429

Summary

Enables PDZ domain binding activity and anion transmembrane transporter activity. Involved in several processes, including anion transport; cellular response to cAMP; and cellular response to fructose stimulus. Located in several cellular components, including apical plasma membrane; brush border membrane; and sperm midpiece. Is integral component of plasma membrane. Orthologous to human SLC26A6 (solute carrier family 26 member 6). [provided by Alliance of Genome Resources, Apr 2022]

Slc26a6 Products (2)

mRNA Protein Name
NM_001408387.1 NP_001395316.1 solute carrier family 26 member 6 isoform 2
NM_134420.5 NP_599252.2 solute carrier family 26 member 6 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables PDZ domain binding IDA
IDA: Inferred from direct assay
16141316 MGI
enables bicarbonate transmembrane transporter activity IDA
IDA: Inferred from direct assay
11842009 MGI
enables chloride transmembrane transporter activity IDA
IDA: Inferred from direct assay
11459928 MGI
enables chloride transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
16141316 MGI
enables chloride:bicarbonate antiporter activity IDA
IDA: Inferred from direct assay
11842009 MGI
enables chloride:bicarbonate antiporter activity IMP
IMP: Inferred from mutant phenotype
20150244 MGI
enables efflux transmembrane transporter activity IDA
IDA: Inferred from direct assay
12217875 MGI
enables formate transmembrane transporter activity IDA
IDA: Inferred from direct assay
11459928 MGI
enables oxalate transmembrane transporter activity IDA
IDA: Inferred from direct assay
12217875 MGI
enables oxalate transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
16141316 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16141316 MGI
enables solute:inorganic anion antiporter activity IDA
IDA: Inferred from direct assay
11459928 MGI
enables solute:inorganic anion antiporter activity IMP
IMP: Inferred from mutant phenotype
16532010 MGI
enables sulfate transmembrane transporter activity IDA
IDA: Inferred from direct assay
12217875 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within bicarbonate transport IDA
IDA: Inferred from direct assay
11842009 MGI
involved in bicarbonate transport IDA
IDA: Inferred from direct assay
12119287 MGI
acts upstream of or within bicarbonate transport IMP
IMP: Inferred from mutant phenotype
19033647 MGI
involved in bicarbonate transport IMP
IMP: Inferred from mutant phenotype
20150244 MGI
involved in cellular response to cAMP IDA
IDA: Inferred from direct assay
22895259 MGI
involved in cellular response to fructose stimulus IDA
IDA: Inferred from direct assay
18496516 MGI
acts upstream of or within chloride transport IDA
IDA: Inferred from direct assay
11459928 MGI
involved in chloride transport IDA
IDA: Inferred from direct assay
12119287 MGI
involved in chloride transport IMP
IMP: Inferred from mutant phenotype
16141316 MGI
involved in epithelial fluid transport IMP
IMP: Inferred from mutant phenotype
18496516 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
19033647 MGI
acts upstream of or within formate transport IDA
IDA: Inferred from direct assay
11459928 MGI
involved in formate transport IDA
IDA: Inferred from direct assay
12119287 MGI
involved in formate transport IMP
IMP: Inferred from mutant phenotype
22895259 MGI
involved in intestinal absorption IMP
IMP: Inferred from mutant phenotype
22021714 MGI
involved in intracellular pH elevation IMP
IMP: Inferred from mutant phenotype
21976599 MGI
involved in mannitol transmembrane transport IMP
IMP: Inferred from mutant phenotype
22021714 MGI
involved in oxalate transport IDA
IDA: Inferred from direct assay
12119287 MGI
involved in oxalate transport IMP
IMP: Inferred from mutant phenotype
16141316 MGI
involved in oxalic acid secretion IMP
IMP: Inferred from mutant phenotype
22021714 MGI
involved in positive regulation of dipeptide transmembrane transport IMP
IMP: Inferred from mutant phenotype
20150244 MGI
involved in regulation of intracellular pH IMP
IMP: Inferred from mutant phenotype
20150244 MGI
involved in sperm capacitation IMP
IMP: Inferred from mutant phenotype
21976599 MGI
involved in sulfate transmembrane transport IDA
IDA: Inferred from direct assay
12119287 MGI
involved in sulfate transmembrane transport IMP
IMP: Inferred from mutant phenotype
16532010 MGI
involved in transepithelial chloride transport IDA
IDA: Inferred from direct assay
11459928 MGI
involved in transepithelial chloride transport IMP
IMP: Inferred from mutant phenotype
22895259 MGI
involved in transepithelial transport IMP
IMP: Inferred from mutant phenotype
16141316 MGI
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
11459928 MGI
located in brush border membrane IDA
IDA: Inferred from direct assay
11459928 MGI
located in membrane IDA
IDA: Inferred from direct assay
11842009 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
11459928 MGI
located in sperm midpiece IDA
IDA: Inferred from direct assay
21976599 MGI
located in vesicle IDA
IDA: Inferred from direct assay
11842009 MGI
located in vesicle membrane IDA
IDA: Inferred from direct assay
16141316 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

solute carrier family 26 member 6

  • anion exchange transporter

  • chloride-formate exchanger

  • pendrin-L1

  • pendrin-like protein 1

  • putative anion transporter-1

Slc26a6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Slc26a6 Q8CIW6 Cftr Mus musculus P26361
Confocal
21976599
Intra
Slc26a6 Q8CIW6 Slc26a3 Mus musculus Q9WVC8
Anti Bait CoIP
21976599
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-159706 S9-A13 Inhibitor / Unkown
HY-154912 PAT1inh-B01 Inhibitor 98.04% Unkown
HY-154912A PAT1inh-B01 hydrochloride Inhibitor 99.87% Unkown
HY-162033 PAT1inh-A0030 Inhibitor / Unkown
HY-RS13140 SLC26A6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22038 Slc26a6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28555 Slc26a6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc26a6 NCBI NCBI:65010