Epcam - epithelial cell adhesion molecule Gene

Also Known as Egp314; Tacstd1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 171577

Summary

Enables Cadherin binding activity involved in cell-cell adhesion. Involved in cell-cell adhesion via plasma-membrane adhesion molecules; negative regulation of apoptotic process; and positive regulation of cell motility. Located in bicellular tight junction; cell surface; and lateral plasma membrane. Is integral component of membrane. Biomarker of middle cerebral artery infarction. Human ortholog(s) of this gene implicated in congenital diarrhea 5 with tufting enteropathy and hereditary nonpolyposis colorectal Cancer type 8. Orthologous to human EPCAM (epithelial cell adhesion molecule). [provided by Alliance of Genome Resources, Apr 2022]

Epcam Products (1)

mRNA Protein Name
NM_138541.2 NP_612550.1 epithelial cell adhesion molecule precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cadherin binding involved in cell-cell adhesion IPI
IPI: Inferred from physical interaction
19276185 RGD
Biological Process GO Annotation Evidence References Source
involved in cell-cell adhesion via plasma-membrane adhesion molecules IDA
IDA: Inferred from direct assay
19276185 RGD
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
19276185 RGD
involved in positive regulation of cell motility IDA
IDA: Inferred from direct assay
19276185 RGD
Cellular Component GO Annotation Evidence References Source
located in bicellular tight junction IDA
IDA: Inferred from direct assay
16054130 RGD
located in cell surface IDA
IDA: Inferred from direct assay
19276185 RGD
located in lateral plasma membrane IDA
IDA: Inferred from direct assay
16054130 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

epithelial cell adhesion molecule

  • ep-CAM

  • epithelial glycoprotein 314

  • tumor-associated calcium signal transducer 1

Recombinant Epcam Proteins

Cat. No. Product Name Accession Purity
HY-P74172 EpCAM/TROP1 Protein, Rat (HEK293, His) O55159 (Q24-T266) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P74173 EpCAM/TROP1 Protein, Rat (HEK293, Fc) O55159 (Q24-T266) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-111183 Neocarzinostatin (solution) 99.9% Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P9954 Catumaxomab 99.82% Unkown

Clinical Phase

Bioactive MoleculesInhibitory Antibodies (4)
Cat. No. Product Name Effect
Purity Phase
HY-P991214 Tucotuzumab celmoleukin 98.797% Phase 3
HY-P99328 Tucotuzumab 99% Phase 2
HY-P99592 Solitomab Inhibitor 98.22% Phase 1
HY-P991646 ING-1 99.0% Phase 1

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15897 LDN-212854 Inhibitor 99.62% Unkown
HY-160066 SYL3C aptamer sodium Ligand 95.31% Unkown
HY-168885 ZSH-512 / Unkown
HY-N3467 Isomexoticin / Unkown
HY-RS04420 EPCAM Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17079 Epcam Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23523 Epcam Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990642 Oportuzumab Inhibitor 99.62% Unkown
HY-P991526 M701 Inhibitor 99.05% Unkown
HY-P991723 Varsetatug Inhibitor 97% Unkown
HY-P991034 Trevotamig Inhibitor 95.539% Unkown
HY-P992145 Zeclantamig / Unkown
HY-P990275 Anti-Mouse CD326/EpCAM Antibody (G8.8) Inhibitor 97.80% Unkown
HY-P991576 Anti-CD326/EPCAM Antibody (3622W94) Inhibitor / Unkown
HY-P990862 Anti-CD326/EpCAM Antibody (Ber-EP4) Inhibitor / Unkown
HY-P992179 AM-928 / Unkown
HY-P992370 HPN601 Inhibitor / Unkown
HY-P991575 AT003 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Epcam NCBI NCBI:4072