Ascl2 - achaete-scute family bHLH transcription factor 2 Gene

Also Known as Mash2; bHLHa45; 2410083I15Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17173

Summary

Enables sequence-specific DNA binding activity. Acts upstream of or within regulation of transcription by RNA polymerase II; somatic stem cell population maintenance; and spongiotrophoblast differentiation. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and musculoskeletal system. Orthologous to human ASCL2 (achaete-scute family bHLH transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Ascl2 Products (1)

mRNA Protein Name
NM_008554.3 NP_032580.2 achaete-scute homolog 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
10611232 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IGI
IGI: Inferred from genetic interaction
10611232 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
24463518 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IGI
IGI: Inferred from genetic interaction
10611232 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
24463518 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IGI
IGI: Inferred from genetic interaction
25620640 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP
IMP: Inferred from mutant phenotype
25620640 MGI
enables bHLH transcription factor binding IPI
IPI: Inferred from physical interaction
10611232 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
9676199 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within T cell differentiation IMP
IMP: Inferred from mutant phenotype
31539517 MGI
involved in T follicular helper cell differentiation IMP
IMP: Inferred from mutant phenotype
24463518 MGI
acts upstream of or within cell differentiation IMP
IMP: Inferred from mutant phenotype
8090202 MGI
involved in chorionic trophoblast cell development IMP
IMP: Inferred from mutant phenotype
7773285 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
8090202 MGI
involved in negative regulation of T-helper 1 cell differentiation IMP
IMP: Inferred from mutant phenotype
24463518 MGI
involved in negative regulation of T-helper 17 cell differentiation IMP
IMP: Inferred from mutant phenotype
24463518 MGI
involved in negative regulation of T-helper 2 cell differentiation IMP
IMP: Inferred from mutant phenotype
24463518 MGI
involved in negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
10611232 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
24463518 MGI
acts upstream of or within placenta development IMP
IMP: Inferred from mutant phenotype
21238448 MGI
involved in positive regulation of T cell migration IMP
IMP: Inferred from mutant phenotype
24463518 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10611232 MGI
involved in positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
10611232 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
24463518 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19796622 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
9676199 MGI
acts upstream of or within somatic stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
19269367 MGI
acts upstream of or within spongiotrophoblast differentiation IMP
IMP: Inferred from mutant phenotype
9331331 MGI
involved in stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
25620640 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
23372768 MGI
located in nucleus IDA
IDA: Inferred from direct assay
19269367 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

achaete-scute homolog 2

  • ASH-2

  • achaete-scute complex homolog 2

  • achaete-scute complex homolog-like 2

  • long transient receptor potential-related channel 5

  • mASH-2

  • mammalian achaete scute homolog 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01079 ASCL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20860 Ascl2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27375 Ascl2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ascl2 NCBI NCBI:430