Mdm4 - transformed mouse 3T3 cell double minute 4 Gene

Also Known as Mdmx; 4933417N07Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17248

Summary

This gene encodes a protein that has been shown to negatively regulate the activity of the tumor suppressor protein p53. Homozygous knockout mice exhibit embryonic lethality as a result of p53-dependent Apoptosis and cell cycle arrest. Amplification of this gene or overexpression of the encoded protein has been linked to a range of human cancers. A pseudogene has been identified on the X chromosome. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2014]

Mdm4 Products (5)

mRNA Protein Name
NM_001302801.1 NP_001289730.1 protein Mdm4 isoform 1
NM_001302802.1 NP_001289731.1 protein Mdm4 isoform 1
NM_001302803.1 NP_001289732.1 protein Mdm4 isoform 2
NM_001302804.1 NP_001289733.1 protein Mdm4 isoform 3
NM_008575.4 NP_032601.2 protein Mdm4 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15916963 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within atrial septum development IGI
IGI: Inferred from genetic interaction
22821713 MGI
acts upstream of or within atrioventricular valve morphogenesis IGI
IGI: Inferred from genetic interaction
22821713 MGI
acts upstream of or within endocardial cushion morphogenesis IGI
IGI: Inferred from genetic interaction
22821713 MGI
acts upstream of or within heart valve development IGI
IGI: Inferred from genetic interaction
22821713 MGI
involved in negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator IMP
IMP: Inferred from mutant phenotype
12101245 MGI
acts upstream of or within positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
14712235 MGI
acts upstream of or within regulation of heart rate IGI
IGI: Inferred from genetic interaction
22821713 MGI
acts upstream of or within ventricular septum development IGI
IGI: Inferred from genetic interaction
22821713 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein Mdm4

  • double minute 4 protein

  • mdm2-like p53-binding protein

  • p53-binding protein Mdm4

  • protein Mdmx

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-10412 CEP-1347 98.50% Phase 3

Pre-clinical Phase

Bioactive Molecules (13)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148409 MMRi62 99.59% Unkown
HY-W097753 4-MDM 99.64% Unkown
HY-123544 RDR03871 MDM2 Inhibitor / Unkown
HY-146806 YL93 Inhibitor / Unkown
HY-151169 MDM2/4-p53-IN-1 MDM2 Inhibitor / Unkown
HY-151170 MDM2/4-p53-IN-2 / Unkown
HY-151171 MDM2/4-p53-IN-3 Inhibitor / Unkown
HY-183831 GPS167 / Unkown
HY-RS08267 MDM4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-158830B FAM labled MDM4-targeting ASO sodium / Unkown
HY-158830C Cy3 labled MDM4-targeting ASO sodium / Unkown
HY-RS16923 Mdm4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23366 Mdm4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mdm4 NCBI NCBI:4194