MDM2/4-p53-IN-3
MDM2/4-p53-IN-3 is a MDM2/4-p53 protein-protein interactions (PPIs) inhibitor (IC50s: 18.5 nM for MDM2-p53, 14.8 nM for MDM4-p53). MDM2/4-p53-IN-3 can be used in the research of cancers, such as colon cancer.
For research use only. We do not sell to patients.
- Formula: C25H24Cl2FN3O3
- Molecular Weight:504.38
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
MDM2/4-p53 protein-protein interactions (PPIs)[1]
MDM2/4-p53-IN-3 (Compound 2a, 1-100 μM, 48 h) inhibits cell proliferation[1].
MDM2/4-p53-IN-3 dissociates p53-MDMs complexes (immunoenzymatic assays) with IC50 values of 18.5 nM (MDM2-p53) and 14.8 nM (MDM4-p53)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:HCT116, SJSA-1, LNCaP, MCF-7
-
Concentration:1-100 μM
-
Incubation Time:48 h (HCT116), 72 h (MCF-7), 96 h (SJSA-1, LNCaP)
-
Result:Inhibited cell proliferation with IC50 values of 23.6 μM (HCT116), 12.6 μM (SJSA-1), 13.1 μM (LNCaP), 14.3 μM (MCF-7).
Chemical Information
-
Molecular Weight 504.38
-
Formula C25H24Cl2FN3O3
-
SMILES
O=C(C([C@@H]1C2=CC=CC(Cl)=C2F)=NN(C3CCCCC3)[C@@]41C(NC5=C4C=CC(Cl)=C5)=O)OCC
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MDM2/4-p53-IN-3 Related Classifications
HY-151171 Related Classifications
Powered by Bioz