Abcc1 - ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Gene

Also Known as MRP; Mrp1; Mdrap; Abcc1a; Abcc1b

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17250

Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein plays an essential role in the defense against toxic compounds and serves as the major high-affinity transporter of leukotriene C4. The encoded protein may also play an essential role in steroid hormone homeostasis as a transporter for steroid Hormones and their metabolites. [provided by RefSeq, Nov 2011]

Abcc1 Products (1)

mRNA Protein Name
NM_008576.3 NP_032602.1 multidrug resistance-associated protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ABC-type glutathione S-conjugate transporter activity IMP
IMP: Inferred from mutant phenotype
9359705 MGI
enables ABC-type vitamin B12 transporter activity IMP
IMP: Inferred from mutant phenotype
19897579 MGI
enables efflux transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
26200696 MGI
enables glutathione transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
26200696 MGI
enables xenobiotic transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
26200696 MGI
Biological Process GO Annotation Evidence References Source
involved in cellular response to amyloid-beta IMP
IMP: Inferred from mutant phenotype
26200696 MGI
involved in cobalamin transport IMP
IMP: Inferred from mutant phenotype
19897579 MGI
involved in cyclic nucleotide transport IMP
IMP: Inferred from mutant phenotype
36070769 MGI
involved in export across plasma membrane IMP
IMP: Inferred from mutant phenotype
26200696 MGI
involved in leukotriene transport IMP
IMP: Inferred from mutant phenotype
9359705 MGI
involved in positive regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
9359705 MGI
involved in response to xenobiotic stimulus IMP
IMP: Inferred from mutant phenotype
9359705 MGI
involved in xenobiotic transport IMP
IMP: Inferred from mutant phenotype
26200696 MGI
Cellular Component GO Annotation Evidence References Source
is active in basal plasma membrane IMP
IMP: Inferred from mutant phenotype
19897579 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
12951053 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

multidrug resistance-associated protein 1

  • ATP-binding cassette, sub-family C (CFTR/MRP), member 1a

  • ATP-binding cassette, sub-family C (CFTR/MRP), member 1b

  • LTC4 transporter

  • glutathione-S-conjugate-translocating ATPase ABCC1

  • leukotriene C(4) transporter

  • multiple drug resistance-associated pro

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N0488A Vincristine 98.60% Yes
HY-B1794 Thiethylperazine 99.91% Unkown
HY-B1794A Thiethylperazine dimaleate 99.99% Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-17013A Dofequidar fumarate Inhibitor 98.0% Phase 3

Pre-clinical Phase

Bioactive Molecules (18)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-19989 MK-571 98.85% Unkown
HY-19989A MK-571 sodium 99.75% Unkown
HY-101453 Ceefourin 1 Inhibitor 99.72% Unkown
HY-N3610 Coclaurine Antagonist 98.97% Unkown
HY-17013 Dofequidar Inhibitor 99.29% Unkown
HY-113805 MC70 Inhibitor 99.50% Unkown
HY-136907 (S)-Verapamil / Unkown
HY-173189 2-5A Inhibitor / Unkown
HY-RS23355 Abcc1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-146676 UR-MB108 Inhibitor / Unkown
HY-17013D Dofequidar sesquifumarate Inhibitor / Unkown
HY-17648 MBL-II-141 Inhibitor / Unkown
HY-182253 WS-691 Modulator / Unkown
HY-A0188 Norzine dimalate / Unkown
HY-D1609 BODIPY FL Verapamil hydrochloride / Unkown
HY-RS00057 ABCC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-B1794S Thiethylperazine-d3 / Unkown
HY-RS16913 Abcc1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Abcc1 NCBI NCBI:4363