Sik1 - salt inducible kinase 1 Gene

Also Known as Msk; Sik; Sik-1; Hrt-20; Snf1lk

Species: Mus musculus

Gene Type: protein coding

Gene ID: 17691

About Sik1

Chromosome 17: 32,063,224-32,074,778 reverse strand.GRCm39:CM001010.3

This gene has 4 transcripts (splice variants), 236 orthologues, 19 paralogues and is associated with 18 phenotypes. Ubiquitous expression in lung adult (RPKM 31.), spleen adult (RPKM 26.) and 27 other tissues.

Summary

Enables several functions, including ATP binding activity; cAMP response element binding protein binding activity; and enzyme binding activity. Involved in several processes, including anoikis; entrainment of circadian clock by photoperiod; and regulation of cellular biosynthetic process. Acts upstream of or within regulation of cell differentiation. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 30. Orthologous to human SIK1 (salt inducible kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Sik1 Products (1)

mRNA	Protein	Name
NM_010831.3	NP_034961.2	serine/threonine-protein kinase SIK1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IDA IDA: Inferred from direct assay	15177563	MGI
enables cAMP response element binding protein binding	IDA IDA: Inferred from direct assay	12200423	MGI
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	17468767	MGI
enables magnesium ion binding	IDA IDA: Inferred from direct assay	15177563	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	19244231	MGI
enables protein kinase binding	IPI IPI: Inferred from physical interaction	12200423	MGI
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	12624099	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in anoikis	IMP IMP: Inferred from mutant phenotype	19622832	MGI
involved in cardiac muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	20140255	MGI
involved in entrainment of circadian clock by photoperiod	IMP IMP: Inferred from mutant phenotype	23993098	MGI
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	15177563	MGI
involved in negative regulation of CREB transcription factor activity	IDA IDA: Inferred from direct assay	12200423	MGI
involved in negative regulation of CREB transcription factor activity	IMP IMP: Inferred from mutant phenotype	23993098	MGI
involved in negative regulation of gluconeogenesis	IDA IDA: Inferred from direct assay	16148943	MGI
involved in negative regulation of triglyceride biosynthetic process	IDA IDA: Inferred from direct assay	19244231	MGI
acts upstream of or within protein phosphorylation	IDA IDA: Inferred from direct assay	12624099	MGI
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	15177563	MGI
involved in regulation of cell differentiation	IEP IEP: Inferred from expression pattern	15177563	MGI
involved in regulation of mitotic cell cycle	IDA IDA: Inferred from direct assay	15177563	MGI
involved in regulation of myotube differentiation	IDA IDA: Inferred from direct assay	17468767	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12200423	MGI
located in nucleus	IDA IDA: Inferred from direct assay	12200423	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Sik1 Protein Structure

STKc_SIK

UBA_SIK1

0
200
400
600
779 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein kinase SIK1	Probable serine/threonine protein kinase SNF1LK (HRT-20) (Myocardial SNF1-like kinase) SNF1-like kinase myocardial SNF1-like kinase salt-inducible protein kinase 1 serine/threonine-protein kinase SNF1-like kinase 1 serine/threonine-protein kinase SNF1LK

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-157442	GLPG3312	Inhibitor	98.63%	Phase 1

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15776	HG-9-91-01	Inhibitor	99.77%	Unkown
HY-101147	YKL-05-099	Inhibitor	99.76%	Unkown
HY-120877	MRT199665	Inhibitor	99.85%	Unkown
HY-120856	ARN-3236	Inhibitor	99.66%	Unkown
HY-120056	YKL-06-061	Inhibitor	99.82%	Unkown
HY-175479	GLPG4970	Inhibitor	99.60%	Unkown
HY-139253	MRIA9	Inhibitor	98.88%	Unkown
HY-171591	SIK2-IN-4	Inhibitor	99.06%	Unkown
HY-182804	SIK2/3-IN-3	Inhibitor	/	Unkown
HY-171590	SIK2-IN-3	Inhibitor	/	Unkown
HY-178014	SIK1-IN-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sik1	NCBI	NCBI:150094