2. Gene
  3. Sik1 - salt inducible kinase 1 Gene

Sik1 - salt inducible kinase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Msk; Sik; Sik-1; Hrt-20; Snf1lk

Gene ID: 17691 | Gene type: protein coding

About Sik1

Chromosome 17: 32,063,224-32,074,778 reverse strand.GRCm39:CM001010.3

This gene has 4 transcripts (splice variants), 236 orthologues, 19 paralogues and is associated with 18 phenotypes. Ubiquitous expression in lung adult (RPKM 31.), spleen adult (RPKM 26.) and 27 other tissues.

Summary

Enables several functions, including ATP binding activity; cAMP response element binding protein binding activity; and Enzyme binding activity. Involved in several processes, including anoikis; entrainment of circadian clock by photoperiod; and regulation of cellular biosynthetic process. Acts upstream of or within regulation of cell differentiation. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 30. Orthologous to human SIK1 (salt inducible kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Sik1 Products(1)

mRNA Protein Name
NM_010831.3 NP_034961.2 serine/threonine-protein kinase SIK1

Sik1 Protein Structure

STKc_SIK

STKc_SIK: cd14071 (25 - 277)

UBA_SIK1

UBA_SIK1: cd14408 (299 - 348)

  • 0
  • 200
  • 400
  • 600
  • 779 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase SIK1

Probable serine/threonine protein kinase SNF1LK (HRT-20) (Myocardial SNF1-like kinase)

SNF1-like kinase

myocardial SNF1-like kinase

salt-inducible protein kinase 1

serine/threonine-protein kinase SNF1-like kinase 1

serine/threonine-protein kinase SNF1LK

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-101147 YKL-05-099 Inhibitor 99.76% Unkown
HY-120856 ARN-3236 Inhibitor 98.60% Unkown
HY-120877 MRT199665 Inhibitor 99.92% Unkown
HY-139253 MRIA9 Inhibitor 98.34% Unkown
HY-157442 GLPG3312 Inhibitor 98.25% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sik1 NCBI NCBI:150094