Ncf1 - neutrophil cytosolic factor 1 Gene

Also Known as NOXO2; Ncf-1; NCF-47K; p47phox; p47-phox; p47

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17969

Summary

Enables superoxide-generating NADPH Oxidase activator activity. Acts upstream of or within several processes, including cellular defense response; hydrogen peroxide biosynthetic process; and neutrophil-mediated killing of symbiont cell. Located in cytoplasm and membrane. Is expressed in several structures, including alimentary system; brain; hemolymphoid system; integumental system; and sensory organ. Used to study chronic granulomatous disease. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome; autosomal recessive chronic granulomatous disease cytochrome b-positive type I; and chronic granulomatous disease. Orthologous to several human genes including NCF1 (neutrophil cytosolic factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Ncf1 Products (2)

mRNA Protein Name
NM_001286037.1 NP_001272966.1 neutrophil cytosol factor 1 isoform a
NM_010876.4 NP_035006.3 neutrophil cytosol factor 1 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
9490028 MGI
enables superoxide-generating NADPH oxidase activator activity IDA
IDA: Inferred from direct assay
8119734 MGI
enables superoxide-generating NADPH oxidase activator activity IMP
IMP: Inferred from mutant phenotype
10987289 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular defense response IMP
IMP: Inferred from mutant phenotype
7650482 MGI
acts upstream of or within defense response to Gram-positive bacterium IMP
IMP: Inferred from mutant phenotype
11907569 MGI
acts upstream of or within defense response to bacterium IMP
IMP: Inferred from mutant phenotype
9116268 MGI
acts upstream of or within defense response to fungus IMP
IMP: Inferred from mutant phenotype
10714686 MGI
acts upstream of or within epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
10987289 MGI
acts upstream of or within hydrogen peroxide biosynthetic process IMP
IMP: Inferred from mutant phenotype
15258578 MGI
acts upstream of or within inflammatory response IMP
IMP: Inferred from mutant phenotype
11867678 MGI
acts upstream of or within leukocyte mediated cytotoxicity IMP
IMP: Inferred from mutant phenotype
17526748 MGI
acts upstream of or within leukotriene metabolic process IMP
IMP: Inferred from mutant phenotype
11867678 MGI
acts upstream of or within neutrophil-mediated killing of fungus IMP
IMP: Inferred from mutant phenotype
11907569 MGI
acts upstream of or within neutrophil-mediated killing of gram-positive bacterium IMP
IMP: Inferred from mutant phenotype
11907569 MGI
acts upstream of or within respiratory burst IMP
IMP: Inferred from mutant phenotype
15626477 MGI
acts upstream of or within respiratory burst involved in defense response IMP
IMP: Inferred from mutant phenotype
10714686 MGI
acts upstream of or within response to bacterium IMP
IMP: Inferred from mutant phenotype
10678931 MGI
acts upstream of or within response to yeast IMP
IMP: Inferred from mutant phenotype
10714686 MGI
acts upstream of or within superoxide anion generation IMP
IMP: Inferred from mutant phenotype
10725280 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11156938 MGI
located in membrane IDA
IDA: Inferred from direct assay
26021615 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neutrophil cytosol factor 1

  • 47 kDa neutrophil oxidase factor

  • NADPH oxidase subunit (47 kD)

  • NADPH oxidase subunit (47kDa)

  • neutrophil NADPH oxidase factor 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS20305 Ncf1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09077 NCF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26813 Ncf1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ncf1 NCBI NCBI:653361