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Nog - noggin Gene

Species: Mus musculus

Gene Type: protein coding

Gene ID: 18121

Summary

Predicted to enable cytokine binding activity and protein homodimerization activity. Involved in several processes, including circulatory system development; negative regulation of cell differentiation; and negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway. Acts upstream of or within several processes, including animal organ development; embryonic morphogenesis; and regulation of signal transduction. Located in extracellular space. Is expressed in several structures, including branchial arch; embryo ectoderm; heart; limb; and sensory organ. Used to study esophageal atresia/tracheoesophageal fistula. Human ortholog(s) of this gene implicated in Huntington's disease; cleft lip; dysostosis (multiple); hyperopia; and proximal symphalangism (multiple). Orthologous to human NOG (noggin). [provided by Alliance of Genome Resources, Apr 2022]

Nog Products (1)

mRNA	Protein	Name
NM_008711.2	NP_032737.1	noggin precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	References	Source
acts upstream of BMP signaling pathway	IDA IDA: Inferred from direct assay	18462699	MGI
involved in BMP signaling pathway	IDA IDA: Inferred from direct assay	17634368	MGI
involved in BMP signaling pathway	IGI IGI: Inferred from genetic interaction	12397106	MGI
acts upstream of or within anatomical structure formation involved in morphogenesis	IGI IGI: Inferred from genetic interaction	16916379	MGI
acts upstream of or within anatomical structure formation involved in morphogenesis	IMP IMP: Inferred from mutant phenotype	16916379	MGI
involved in atrial cardiac muscle tissue morphogenesis	IMP IMP: Inferred from mutant phenotype	17218603	MGI
acts upstream of or within axial mesoderm development	IMP IMP: Inferred from mutant phenotype	16712836	MGI
acts upstream of or within axon guidance	IMP IMP: Inferred from mutant phenotype	12435358	MGI
acts upstream of or within brain development	IMP IMP: Inferred from mutant phenotype	12397106	MGI
acts upstream of cartilage development	IDA IDA: Inferred from direct assay	10684250	MGI
involved in cell population proliferation	IGI IGI: Inferred from genetic interaction	12397106	MGI
acts upstream of or within cellular response to BMP stimulus	IDA IDA: Inferred from direct assay	20501701	MGI
acts upstream of or within central nervous system development	IMP IMP: Inferred from mutant phenotype	10688202	MGI
involved in cranial skeletal system development	IGI IGI: Inferred from genetic interaction	12397106	MGI
involved in endocardial cushion formation	IMP IMP: Inferred from mutant phenotype	17218603	MGI
acts upstream of or within endoderm development	IDA IDA: Inferred from direct assay	24835669	MGI
acts upstream of or within endoderm formation	IDA IDA: Inferred from direct assay	18462699	MGI
acts upstream of epithelial cell proliferation	IGI IGI: Inferred from genetic interaction	18028901	MGI
acts upstream of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	18028901	MGI
involved in epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	17218603	MGI
involved in exploration behavior	IMP IMP: Inferred from mutant phenotype	17634368	MGI
acts upstream of or within face morphogenesis	IMP IMP: Inferred from mutant phenotype	16712836	MGI
involved in fibroblast growth factor receptor signaling pathway	IGI IGI: Inferred from genetic interaction	12397106	MGI
involved in forebrain development	IGI IGI: Inferred from genetic interaction	10688202	MGI
involved in heart trabecula morphogenesis	IMP IMP: Inferred from mutant phenotype	17218603	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	17359964	MGI
involved in long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	17634368	MGI
acts upstream of or within lung morphogenesis	IMP IMP: Inferred from mutant phenotype	16712836	MGI
involved in membranous septum morphogenesis	IMP IMP: Inferred from mutant phenotype	17218603	MGI
acts upstream of or within mesenchymal cell differentiation	IMP IMP: Inferred from mutant phenotype	18028901	MGI
acts upstream of or within mesoderm formation	IDA IDA: Inferred from direct assay	18462699	MGI
acts upstream of or within motor neuron axon guidance	IMP IMP: Inferred from mutant phenotype	12435358	MGI
acts upstream of or within negative regulation of BMP signaling pathway	IDA IDA: Inferred from direct assay	15110716	MGI
involved in negative regulation of BMP signaling pathway	IDA IDA: Inferred from direct assay	17360443	MGI
acts upstream of or within negative regulation of BMP signaling pathway	IGI IGI: Inferred from genetic interaction	19852960	MGI
acts upstream of or within negative regulation of BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	16712836	MGI
involved in negative regulation of BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	17218603	MGI
acts upstream of or within negative regulation of apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	16712836	MGI
involved in negative regulation of astrocyte differentiation	IMP IMP: Inferred from mutant phenotype	18028109	MGI
involved in negative regulation of cardiac epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	17218603	MGI
involved in negative regulation of cardiac muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	17218603	MGI
acts upstream of or within negative regulation of cartilage development	IDA IDA: Inferred from direct assay	10684250	MGI
acts upstream of or within negative regulation of gene expression	IDA IDA: Inferred from direct assay	21624478	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17218603	MGI
acts upstream of or within neural plate morphogenesis	IMP IMP: Inferred from mutant phenotype	16712836	MGI
acts upstream of or within neural tube closure	IMP IMP: Inferred from mutant phenotype	16712836	MGI
acts upstream of or within neural tube development	IMP IMP: Inferred from mutant phenotype	9585504	MGI
acts upstream of or within notochord morphogenesis	IMP IMP: Inferred from mutant phenotype	16916379	MGI
involved in osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	10780858	MGI
involved in outflow tract morphogenesis	IMP IMP: Inferred from mutant phenotype	17218603	MGI
acts upstream of or within pattern specification process	IMP IMP: Inferred from mutant phenotype	12397106	MGI
involved in pharyngeal arch artery morphogenesis	IMP IMP: Inferred from mutant phenotype	17218603	MGI
acts upstream of or within pituitary gland development	IMP IMP: Inferred from mutant phenotype	17359964	MGI
involved in positive regulation of branching involved in ureteric bud morphogenesis	IDA IDA: Inferred from direct assay	12141440	MGI
acts upstream of or within positive regulation of epithelial cell proliferation	IGI IGI: Inferred from genetic interaction	18028901	MGI
acts upstream of or within positive regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	18028901	MGI
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	17218603	MGI
involved in positive regulation of glomerulus development	IDA IDA: Inferred from direct assay	12141440	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9585504	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	9585504	MGI
involved in presynaptic modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	17634368	MGI
acts upstream of or within prostatic bud formation	IMP IMP: Inferred from mutant phenotype	18028901	MGI
acts upstream of or within regulation of BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	17359964	MGI
involved in regulation of neuronal synaptic plasticity	IMP IMP: Inferred from mutant phenotype	17634368	MGI
involved in short-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	17634368	MGI
acts upstream of or within skeletal system development	IMP IMP: Inferred from mutant phenotype	11784076	MGI
involved in smoothened signaling pathway	IGI IGI: Inferred from genetic interaction	12397106	MGI
acts upstream of or within somite development	IMP IMP: Inferred from mutant phenotype	16712836	MGI
involved in specification of segmental identity, mandibular segment	IGI IGI: Inferred from genetic interaction	11784076	MGI
acts upstream of or within spinal cord development	IMP IMP: Inferred from mutant phenotype	16712836	MGI
acts upstream of or within stem cell differentiation	IMP IMP: Inferred from mutant phenotype	18028901	MGI
acts upstream of or within ureteric bud development	IDA IDA: Inferred from direct assay	12141440	MGI
involved in ureteric bud formation	IDA IDA: Inferred from direct assay	17522159	MGI
acts upstream of or within urogenital system development	IMP IMP: Inferred from mutant phenotype	18028901	MGI
involved in ventricular compact myocardium morphogenesis	IMP IMP: Inferred from mutant phenotype	17218603	MGI
involved in ventricular septum morphogenesis	IMP IMP: Inferred from mutant phenotype	17218603	MGI
involved in visual learning	IMP IMP: Inferred from mutant phenotype	17634368	MGI
involved in wound healing	IMP IMP: Inferred from mutant phenotype	18028109	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular space	IDA IDA: Inferred from direct assay	15110716	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
noggin

Recombinant Nog Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7086	Noggin Protein, Mouse (CHO)	P97466 (L20-C232)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70785	Noggin Protein, Mouse (HEK293, His)	P97466 (Q28-C232)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73323	Noggin Protein, Mouse (HEK293, Fc)	P97466 (Q28-C232)	≥ 90%, as determined by Bis-Tris PAGE.
HY-P700286	Noggin Protein, Mouse (HEK293)	P97466 (Q28-C232)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99836	Cudarolimab	Inhibitor	95.00%	Phase 1
HY-P991587	SAR-446523	Inhibitor	99.76%	Phase 1

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-164899	2A3		99.92%	Unkown
HY-163532	FLS-359	Modulator	95.41%	Unkown
HY-170452	MDM2 ligand 4	Ligand	/	Unkown
HY-175236	SF-9-2		/	Unkown
HY-184500	TNG917	Inhibitor	/	Unkown
HY-RS09410	NOG Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17067	Nog Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23511	Nog Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99618	Fidasimtamab	Inhibitor	95.00%	Unkown
HY-P992381	IBI352g4a		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nog	NCBI	NCBI:9241