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Npm1 - nucleophosmin 1 Gene

Also Known as B23; Npm; NO38

Species: Mus musculus

Gene Type: protein coding

Gene ID: 18148

Summary

Enables identical protein binding activity; protein N-terminus binding activity; and rRNA binding activity. Involved in positive regulation of transcription by RNA polymerase II and protein stabilization. Acts upstream of or within several processes, including positive regulation of protein modification process; regulation of gene expression; and ribosome biogenesis. Located in centrosome; cytosol; and nuclear lumen. Part of large ribosomal subunit and small ribosomal subunit. Is expressed in several structures, including central nervous system; early conceptus; oocyte; and small intestine crypt of lieberkuhn. Used to study myelodysplastic syndrome. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human NPM1 (nucleophosmin 1). [provided by Alliance of Genome Resources, Apr 2022]

Npm1 Products (3)

mRNA	Protein	Name
NM_001252260.1	NP_001239189.1	nucleophosmin isoform 2
NM_001252261.1	NP_001239190.1	nucleophosmin isoform 3
NM_008722.3	NP_032748.1	nucleophosmin isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA binding	IDA IDA: Inferred from direct assay	16376875	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	24616519	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9642267	MGI
enables rRNA binding	IDA IDA: Inferred from direct assay	15596447	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cell volume homeostasis	IDA IDA: Inferred from direct assay	18809582	MGI
acts upstream of or within cell volume homeostasis	IMP IMP: Inferred from mutant phenotype	18809582	MGI
acts upstream of or within negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	18625840	MGI
acts upstream of or within negative regulation of gene expression	IGI IGI: Inferred from genetic interaction	18625840	MGI
acts upstream of or within negative regulation of mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	16376875	MGI
acts upstream of or within nucleocytoplasmic transport	IDA IDA: Inferred from direct assay	15485902	MGI
acts upstream of or within positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	18809582	MGI
acts upstream of or within positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	18809582	MGI
acts upstream of or within positive regulation of cellular biosynthetic process	IDA IDA: Inferred from direct assay	18809582	MGI
acts upstream of or within positive regulation of cellular biosynthetic process	IMP IMP: Inferred from mutant phenotype	18809582	MGI
acts upstream of or within positive regulation of centrosome duplication	IGI IGI: Inferred from genetic interaction	17015463	MGI
acts upstream of or within positive regulation of protein kinase activity	IDA IDA: Inferred from direct assay	17015463	MGI
involved in positive regulation of protein localization to nucleolus	IDA IDA: Inferred from direct assay	20513429	MGI
acts upstream of or within positive regulation of protein localization to nucleolus	IMP IMP: Inferred from mutant phenotype	18625840	MGI
acts upstream of or within positive regulation of protein ubiquitination	IMP IMP: Inferred from mutant phenotype	18625840	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	19160485	MGI
acts upstream of or within post-transcriptional regulation of gene expression	IMP IMP: Inferred from mutant phenotype	18625840	MGI
acts upstream of or within protein localization	IMP IMP: Inferred from mutant phenotype	16199867	MGI
acts upstream of or within protein stabilization	IGI IGI: Inferred from genetic interaction	18625840	MGI
acts upstream of or within protein stabilization	IMP IMP: Inferred from mutant phenotype	18625840	MGI
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	19160485	MGI
acts upstream of or within regulation of DNA damage response, signal transduction by p53 class mediator	IGI IGI: Inferred from genetic interaction	16199867	MGI
acts upstream of or within regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	15485902	MGI
acts upstream of or within regulation of cell growth	IDA IDA: Inferred from direct assay	18809582	MGI
acts upstream of or within regulation of centrosome duplication	IMP IMP: Inferred from mutant phenotype	16007073	MGI
acts upstream of or within regulation of protein stability	IMP IMP: Inferred from mutant phenotype	18625840	MGI
acts upstream of or within ribosomal large subunit biogenesis	IDA IDA: Inferred from direct assay	18809582	MGI
acts upstream of or within ribosomal large subunit biogenesis	IMP IMP: Inferred from mutant phenotype	18809582	MGI
acts upstream of or within ribosomal large subunit export from nucleus	IMP IMP: Inferred from mutant phenotype	18809582	MGI
acts upstream of or within ribosomal small subunit biogenesis	IDA IDA: Inferred from direct assay	18809582	MGI
acts upstream of or within ribosomal small subunit biogenesis	IMP IMP: Inferred from mutant phenotype	18809582	MGI
acts upstream of or within ribosomal small subunit export from nucleus	IDA IDA: Inferred from direct assay	18809582	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in centrosome	IDA IDA: Inferred from direct assay	16297385	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	16648475	MGI
located in cytosol	IDA IDA: Inferred from direct assay	18809582	MGI
located in granular component	IDA IDA: Inferred from direct assay	15485902	MGI
part of large ribosomal subunit	IDA IDA: Inferred from direct assay	18809582	MGI
located in nuclear speck	IDA IDA: Inferred from direct assay	16376875	MGI
located in nucleolus	IDA IDA: Inferred from direct assay	2100262	MGI
located in nucleoplasm	IDA IDA: Inferred from direct assay	12374805	MGI
located in nucleus	IDA IDA: Inferred from direct assay	16648475	MGI
part of small ribosomal subunit	IDA IDA: Inferred from direct assay	18809582	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
nucleophosmin	nucleolar phosphoprotein B23 nucleolar protein NO38 numatrin

Recombinant Npm1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71574	Nucleophosmin/Npm1 Protein, Mouse (His-SUMO)	Q61937 (M1-L292)	≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (19)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-156794	Enzomenib	Inhibitor	99.88%	Unkown
HY-136360	MI-3454	Inhibitor	98.03%	Unkown
HY-162350	TDI-11055		98.18%	Unkown
HY-162265A	UCM-13369 dihydrochloride	Inducer	99.87%	Unkown
HY-172416	Balomenib	Inhibitor	99.81%	Unkown
HY-N10264	Avrainvillamide		95.08%	Unkown
HY-164279	YTR107		95.33%	Unkown
HY-156794A	Enzomenib enantiomer	Inhibitor	98.01%	Unkown
HY-162265	UCM-13369	Inducer	/	Unkown
HY-114162B	VTP50469 mesylate		/	Unkown
HY-122670	VS-II-173		/	Unkown
HY-181690	Menin-MLL-IN-37	Inhibitor	/	Unkown
HY-208723	MAP3K1-IN-1	Inhibitor	/	Unkown
HY-E70760	NPM1 ALK Recombinant Human Active Protein Kinase		/	Unkown
HY-E70761	NPM1 ALK F1174L Recombinant Human Active Protein Kinase		/	Unkown
HY-RS09490	NPM1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17071	Npm1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18762	Gja1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23515	Npm1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Npm1	NCBI	NCBI:4869