Npr3 - natriuretic peptide receptor 3 Gene

Also Known as lgj; EF-2; stri; ANP-C; NPR-C; ANPR-C

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18162

Summary

Predicted to enable several functions, including chloride ion binding activity; peptide receptor activity; and protein homodimerization activity. Involved in several processes, including negative regulation of cold-induced thermogenesis; osteoclast proliferation; and positive regulation of urine volume. Predicted to be located in membrane. Predicted to be part of protein-containing complex. Is expressed in several structures, including central nervous system; genitourinary system; gut; heart and pericardium; and lung. Used to study bone disease. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human NPR3 (natriuretic peptide receptor 3). [provided by Alliance of Genome Resources, Apr 2022]

Npr3 Products (6)

mRNA Protein Name
NM_001039181.2 NP_001034270.1 atrial natriuretic peptide receptor 3 isoform b precursor
NM_001286395.2 NP_001273324.1 atrial natriuretic peptide receptor 3 isoform c
NM_001411434.1 NP_001398363.1 atrial natriuretic peptide receptor 3 isoform c
NM_001411435.1 NP_001398364.1 atrial natriuretic peptide receptor 3 isoform d
NM_001411436.1 NP_001398365.1 atrial natriuretic peptide receptor 3 isoform d
NM_008728.3 NP_032754.2 atrial natriuretic peptide receptor 3 isoform a precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in angiogenesis IMP
IMP: Inferred from mutant phenotype
30586761 MGI
involved in blood vessel remodeling IMP
IMP: Inferred from mutant phenotype
30586761 MGI
involved in negative regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
22307324 MGI
involved in osteoclast proliferation IMP
IMP: Inferred from mutant phenotype
10377427 MGI
involved in positive regulation of urine volume IMP
IMP: Inferred from mutant phenotype
10377427 MGI
involved in regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
10377427 MGI
involved in regulation of osteoblast proliferation IMP
IMP: Inferred from mutant phenotype
10377427 MGI
involved in response to ischemia IMP
IMP: Inferred from mutant phenotype
30586761 MGI
involved in skeletal system development IDA
IDA: Inferred from direct assay
10377427 MGI
involved in skeletal system development IMP
IMP: Inferred from mutant phenotype
10377427 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

atrial natriuretic peptide receptor 3

  • Nppc receptor

  • atrial natriuretic peptide clearance receptor

  • atrial natriuretic peptide receptor type C

  • longjohn

  • strigosus

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P1419 AP 811 Antagonist 99.64% Unkown
HY-P1419A AP 811 acetate Antagonist / Unkown
HY-RS09499 NPR3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09501 NPRL3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19149 Npr3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25640 Npr3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Npr3 NCBI NCBI:4883