Musk - muscle, skeletal, receptor tyrosine kinase Gene

Also Known as Mlk; Mdk4; Nsk1; Nsk2; Nsk3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18198

Summary

This gene encodes a member of the protein tyrosine kinase family. The encoded protein is a type 1 receptor-like protein located in muscle membrane that is activated by the heparan sulfate proteoglycan agrin released by nerve cells. The encoded protein activates signaling cascades responsible for multiple aspects of motor neuron and muscle development, including organization of the postsynaptic membrane, synaptic gene transcription, patterning of skeletal muscle, anchoring of acetylcholinesterase, and guidance of motor axons. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Musk Products (6)

mRNA Protein Name
NM_001037127.2 NP_001032204.2 muscle, skeletal receptor tyrosine-protein kinase isoform 1
NM_001037128.1 NP_001032205.1 muscle, skeletal receptor tyrosine-protein kinase isoform 2
NM_001037129.1 NP_001032206.1 muscle, skeletal receptor tyrosine-protein kinase isoform 3
NM_001037130.1 NP_001032207.1 muscle, skeletal receptor tyrosine-protein kinase isoform 5
NM_001165996.1 NP_001159468.1 muscle, skeletal receptor tyrosine-protein kinase isoform 6
NM_010944.2 NP_035074.2 muscle, skeletal receptor tyrosine-protein kinase isoform 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables PDZ domain binding IPI
IPI: Inferred from physical interaction
17576800 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12165471 MGI
enables protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
14622576 MGI
enables protein tyrosine kinase activity IGI
IGI: Inferred from genetic interaction
14622576 MGI
enables protein tyrosine kinase activity IMP
IMP: Inferred from mutant phenotype
8653787 MGI
Biological Process GO Annotation Evidence References Source
involved in enzyme-linked receptor protein signaling pathway IDA
IDA: Inferred from direct assay
18848351 MGI
involved in enzyme-linked receptor protein signaling pathway IGI
IGI: Inferred from genetic interaction
8653787 MGI
involved in enzyme-linked receptor protein signaling pathway IMP
IMP: Inferred from mutant phenotype
14622576 MGI
acts upstream of motor neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
11312299 MGI
acts upstream of or within neuromuscular junction development IGI
IGI: Inferred from genetic interaction
12165471 MGI
involved in positive regulation of Rac protein signal transduction IDA
IDA: Inferred from direct assay
16794080 MGI
involved in positive regulation of Rac protein signal transduction IGI
IGI: Inferred from genetic interaction
14622576 MGI
involved in positive regulation of Rac protein signal transduction IMP
IMP: Inferred from mutant phenotype
8653787 MGI
acts upstream of or within positive regulation of motor neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
11312299 MGI
involved in positive regulation of protein geranylgeranylation IMP
IMP: Inferred from mutant phenotype
14622576 MGI
involved in positive regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
14622576 MGI
involved in positive regulation of skeletal muscle acetylcholine-gated channel clustering IDA
IDA: Inferred from direct assay
18848351 MGI
involved in positive regulation of skeletal muscle acetylcholine-gated channel clustering IGI
IGI: Inferred from genetic interaction
8653787 MGI
involved in positive regulation of skeletal muscle acetylcholine-gated channel clustering IMP
IMP: Inferred from mutant phenotype
14622576 MGI
acts upstream of or within receptor clustering IGI
IGI: Inferred from genetic interaction
12165471 MGI
acts upstream of or within receptor clustering IMP
IMP: Inferred from mutant phenotype
11395002 MGI
acts upstream of or within regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
10320756 MGI
acts upstream of or within regulation of synaptic assembly at neuromuscular junction IMP
IMP: Inferred from mutant phenotype
8653786 MGI
involved in skeletal muscle acetylcholine-gated channel clustering IMP
IMP: Inferred from mutant phenotype
11323662 MGI
Cellular Component GO Annotation Evidence References Source
located in membrane IDA
IDA: Inferred from direct assay
20053883 MGI
is active in neuromuscular junction IDA
IDA: Inferred from direct assay
14622576 MGI
located in neuromuscular junction IDA
IDA: Inferred from direct assay
17119023 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
14678832 MGI
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
9136771 MGI
located in postsynaptic membrane IDA
IDA: Inferred from direct assay
19038220 MGI
located in synapse IDA
IDA: Inferred from direct assay
20053883 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

muscle, skeletal receptor tyrosine-protein kinase

  • muscle localized kinase 2

  • muscle-specific kinase receptor

  • muscle-specific tyrosine-protein kinase receptor

Musk Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Musk Q61006 Dok7 Mus musculus Q18PE0
X-Ray Diffraction
20603078
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Musk Proteins

Cat. No. Product Name Accession Purity
HY-P71568 MUSK Protein, Mouse (Myc, His-SUMO) Q61006-1 (E22-T494) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-A0287 Clomiphene / Unkown

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P991066 Adimanebart 99.739% Phase 2

Pre-clinical Phase

Bioactive Molecules (13)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0633 Muscone Inhibitor 98.0% Unkown
HY-15590 AZ-23 Inhibitor 98.92% Unkown
HY-N3127 Orobol Inhibitor 99.74% Unkown
HY-W100026 Galaxolide 76.44% Unkown
HY-P5438 Srctide Substrate 99.71% Unkown
HY-N2045 Musk ketone 99.21% Unkown
HY-W744618 Ambrettolide 99.53% Unkown
HY-W721109 (R)-(-)-Muscone Agonist 98.61% Unkown
HY-116108 Musk tibetene Ligand 98.0% Unkown
HY-RS08852 MUSK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-171982 ATII / Unkown
HY-RS17455 Musk Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23912 Musk Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990473 Anti-MUSK Antibody Inhibitor 99.81% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Musk NCBI NCBI:4593