Pck1 - phosphoenolpyruvate carboxykinase 1, cytosolic Gene

Also Known as PEPCK; Pck-1; PEPCK-C

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18534

Summary

Enables phosphoenolpyruvate carboxykinase (GTP) activity. Involved in oxaloacetate metabolic process and positive regulation of memory T cell differentiation. Acts upstream of or within several processes, including cellular response to potassium ion starvation; gluconeogenesis; and glycerol biosynthetic process from pyruvate. Located in cytosol. Is expressed in several structures, including alimentary system; brown fat; liver; and urinary system. Human ortholog(s) of this gene implicated in Alzheimer's disease and type 2 diabetes mellitus. Orthologous to human PCK1 (phosphoenolpyruvate carboxykinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Pck1 Products (1)

mRNA Protein Name
NM_011044.3 NP_035174.1 phosphoenolpyruvate carboxykinase, cytosolic [GTP]

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables phosphoenolpyruvate carboxykinase (GTP) activity IMP
IMP: Inferred from mutant phenotype
10938127 MGI
enables phosphoenolpyruvate carboxykinase activity IMP
IMP: Inferred from mutant phenotype
11792850 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to potassium ion starvation IDA
IDA: Inferred from direct assay
19458124 MGI
acts upstream of or within gluconeogenesis IDA
IDA: Inferred from direct assay
11916968 MGI
involved in gluconeogenesis IDA
IDA: Inferred from direct assay
19643083 MGI
involved in gluconeogenesis IMP
IMP: Inferred from mutant phenotype
10938127 MGI
involved in glyceraldehyde-3-phosphate biosynthetic process IMP
IMP: Inferred from mutant phenotype
11792850 MGI
acts upstream of or within glycerol biosynthetic process from pyruvate IMP
IMP: Inferred from mutant phenotype
11792850 MGI
acts upstream of or within lipid metabolic process IMP
IMP: Inferred from mutant phenotype
11792850 MGI
involved in oxaloacetate metabolic process IMP
IMP: Inferred from mutant phenotype
29230018 MGI
involved in positive regulation of memory T cell differentiation IMP
IMP: Inferred from mutant phenotype
29230018 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19458124 MGI
acts upstream of or within response to bacterium IEP
IEP: Inferred from expression pattern
23012479 MGI
Cellular Component GO Annotation Evidence References Source
is active in cytosol IDA
IDA: Inferred from direct assay
19458124 MGI
located in cytosol IDA
IDA: Inferred from direct assay
19458124 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

phosphoenolpyruvate carboxykinase, cytosolic [GTP]

  • phosphoenolpyruvate carboxykinase, cytosolic

  • phosphoenolpyruvate carboxylase

  • serine-protein kinase PCK1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-116688 2-Hydroxy-4-(methylthio)butyric acid 88.0% Unkown
HY-N2368 Arecaidine 99.63% Unkown
HY-175266 MI1013 99.10% Unkown
HY-RS10152 PCK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17590 Pck1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24050 Pck1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pck1 NCBI NCBI:5105