Pde1b - phosphodiesterase 1B, Ca2+-calmodulin dependent Gene

Also Known as Pde1b1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18574

Summary

Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity; calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity; and calmodulin-dependent cyclic-nucleotide phosphodiesterase activity. Acts upstream of or within several processes, including response to amphetamine; serotonin metabolic process; and visual learning. Predicted to be located in cytoplasm. Predicted to be active in neuronal cell body. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skeleton. Orthologous to human PDE1B (phosphodiesterase 1B). [provided by Alliance of Genome Resources, Apr 2022]

Pde1b Products (3)

mRNA Protein Name
NM_001285890.1 NP_001272819.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 2
NM_001357980.1 NP_001344909.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 3
NM_008800.2 NP_032826.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 1

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of positive effect dopamine catabolic process IMP
IMP: Inferred from mutant phenotype
17559891 MGI
acts upstream of or within locomotory behavior IMP
IMP: Inferred from mutant phenotype
12077213 MGI
acts upstream of or within response to amphetamine IGI
IGI: Inferred from genetic interaction
17010100 MGI
acts upstream of or within response to amphetamine IMP
IMP: Inferred from mutant phenotype
17010100 MGI
acts upstream of or within serotonin metabolic process IMP
IMP: Inferred from mutant phenotype
17559891 MGI
acts upstream of or within signal transduction IMP
IMP: Inferred from mutant phenotype
12077213 MGI
acts upstream of or within visual learning IGI
IGI: Inferred from genetic interaction
17010100 MGI
acts upstream of or within visual learning IMP
IMP: Inferred from mutant phenotype
12077213 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B

calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B

  • 63 kDa Cam-PDE

  • cam-PDE 1B

  • phosphodiesterase 1B, Ca2+-calmodulin dependent, 63 kDa

  • phosphodiesterase 1B1, Ca2+-calmodulin dependent, 63 kDa

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-12501A ITI-214 Inhibitor 99.56% Phase 2

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-136569 DSR-141562 Inhibitor 99.98% Unkown
HY-101490 PDE1-IN-2 Inhibitor 98.0% Unkown
HY-12501 ITI-214 free base Inhibitor 98.0% Unkown
HY-120741 PF-04822163 Inhibitor / Unkown
HY-120195 PF-04677490 Inhibitor / Unkown
HY-120195A PF-04827736 Inhibitor / Unkown
HY-147946 PDE1-IN-4 Inhibitor / Unkown
HY-180803 LH17 Inhibitor / Unkown
HY-RS10211 PDE1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17837 Pde1b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24305 Pde1b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pde1b NCBI NCBI:5153