PDE1B - phosphodiesterase 1B Gene

Also Known as PDE1B1; PDES1B; HEL-S-79p

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5153

About PDE1B

Cytogenetic location: 12q13.2 Genomic coordinates (GRCh38): 12:54,549,601-54,579,239 (from NCBI)

This gene has 9 transcripts (splice variants), 128 orthologues and 20 paralogues. Broad expression in brain (RPKM 8.5), fat (RPKM 6.8) and 19 other tissues.

Summary

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

PDE1B Products (6)

mRNA Protein Name
NM_000924.4 NP_000915.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 1
NM_001165975.3 NP_001159447.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 2
NM_001288768.2 NP_001275697.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 3
NM_001288769.2 NP_001275698.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 4
NM_001315534.2 NP_001302463.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 3
NM_001315535.2 NP_001302464.1 dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
IDA: Inferred from direct assay
14687666 GOA
enables 3',5'-cyclic-AMP phosphodiesterase activity IMP
IMP: Inferred from mutant phenotype
8855339 GOA
enables 3',5'-cyclic-GMP phosphodiesterase activity IDA
IDA: Inferred from direct assay
14687666 GOA
enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity IDA
IDA: Inferred from direct assay
9419816 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21044950 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to granulocyte macrophage colony-stimulating factor stimulus IDA
IDA: Inferred from direct assay
14687666 GOA
involved in cellular response to macrophage colony-stimulating factor stimulus IDA
IDA: Inferred from direct assay
14687666 GOA
involved in monocyte differentiation IEP
IEP: Inferred from expression pattern
14687666 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
8855339 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDE1B Protein Structure

PDEase_I_N

PDEase_I_N: 3'5'-cyclic nucleotide phosphodiesterase N-terminal (77 - 137)

PDEase_I

PDEase_I: 3'5'-cyclic nucleotide phosphodiesterase (222 - 450)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 536 a.a.
Protein Preferred Names Protein Names

dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B

calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B

  • 63 kDa Cam-PDE

PDE1B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PDE1B Q01064 POT1 Homo sapiens Q9NUX5
Pull Down
21044950
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PDE1B Proteins

Cat. No. Product Name Accession Purity
HY-P75960 PDE1B Protein, Human (sf9, His-GST) Q01064 (M1-D536) ≥ 90%, as determined by reducing SDS-PAGE.

PDE1B Antibodies

Cat. No. Product Name Application Reactivity
HY-P81808 PDE1B Antibody (YA1553) WB Human, Mouse, Rat
HY-P81808A PDE1B Antibody (YA1553)(PBS only) WB Human, Mouse, Rat
HY-P84454 PDE1B Antibody (YA4151) WB, IHC-P, FC, ELISA Human, Rat
HY-P84454A PDE1B Antibody (YA4151)(PBS only) WB, IHC-P, FC, ELISA Human, Rat
HY-P84455 PDE1B Antibody (YA4152) WB, FC, ELISA Human, Mouse, Monkey
HY-P84455A PDE1B Antibody (YA4152)(PBS only) WB, FC, ELISA Human, Mouse, Monkey

Related Diseases

Diseases Alias
Impotence

  • Erectile Dysfunction

  • Sexual Impotence

  • Erectile Dysfunction Adverse Event
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-12501A ITI-214 Inhibitor 99.56% Phase 2

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-136569 DSR-141562 Inhibitor 99.98% Unkown
HY-101490 PDE1-IN-2 Inhibitor 98.0% Unkown
HY-12501 ITI-214 free base Inhibitor 98.0% Unkown
HY-120741 PF-04822163 Inhibitor / Unkown
HY-120195 PF-04677490 Inhibitor / Unkown
HY-120195A PF-04827736 Inhibitor / Unkown
HY-147946 PDE1-IN-4 Inhibitor / Unkown
HY-180803 LH17 Inhibitor / Unkown
HY-RS10211 PDE1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17837 Pde1b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24305 Pde1b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PDE1B VGNC VGNC:68753
Mus musculus PDE1B MGD MGI:97523
Canis familiaris PDE1B VGNC VGNC:44349
Macaca mulatta PDE1B VGNC VGNC:75910
Rattus norvegicus PDE1B RGD RGD:3278
Bos taurus PDE1B VGNC VGNC:32672
Others PDE1B NCBI