Pde3b - phosphodiesterase 3B, cGMP-inhibited Gene

Also Known as 9830102A01Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18576

Summary

Enables protein kinase B binding activity. Acts upstream of or within several processes, including cellular response to Insulin stimulus; glucose homeostasis; and regulation of Insulin secretion. Located in Golgi apparatus; endoplasmic reticulum; and membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human PDE3B (phosphodiesterase 3B). [provided by Alliance of Genome Resources, Apr 2022]

Pde3b Products (1)

mRNA Protein Name
NM_011055.2 NP_035185.2 cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
IDA: Inferred from direct assay
10454575 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
29768196 MGI
enables protein kinase B binding IPI
IPI: Inferred from physical interaction
10454575 MGI
Biological Process GO Annotation Evidence References Source
involved in cellular response to insulin stimulus IEP
IEP: Inferred from expression pattern
10454575 MGI
acts upstream of or within endocrine pancreas development IDA
IDA: Inferred from direct assay
14736883 MGI
acts upstream of or within glucose homeostasis IDA
IDA: Inferred from direct assay
14736883 MGI
acts upstream of or within regulation of insulin secretion IDA
IDA: Inferred from direct assay
14736883 MGI
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
10952971 MGI
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
10952971 MGI
located in membrane IDA
IDA: Inferred from direct assay
10454575 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B

cGMP-inhibited 3',5'-cyclic phosphodiesterase B

  • CGI-PDE B

  • CGIPDE1

  • cyclic GMP-inhibited phosphodiesterase B

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-U00186 K134 Inhibitor 99.76% Phase 2
HY-145924 BAY 2666605 Inhibitor 99.74% Phase 1

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-101312 Cilostamide Inhibitor 99.13% Unkown
HY-136350 BRD9500 Modulator 98.41% Unkown
HY-163285 PDE3B-IN-1 Inhibitor 99.60% Unkown
HY-136350B (S)-BRD9500 Control 99.67% Unkown
HY-112631 OPC 33540 Inhibitor / Unkown
HY-168966 JNJ-54082730 / Unkown
HY-179595 GSK4394835A Inhibitor / Unkown
HY-RS10219 PDE3B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18399 Pde3b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24880 Pde3b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pde3b NCBI NCBI:5140