2. Gene
  3. Prkcb - protein kinase C, beta Gene

Prkcb - protein kinase C, beta Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Pkcb; PKC-B; Prkcb1; Prkcb2; PKC-Beta

Gene ID: 18751 | Gene type: protein coding

About Prkcb

Chromosome 7: 121,887,974-122,233,625 forward strand.GRCm39:CM001000.3

This gene has 8 transcripts (splice variants), 287 orthologues, 9 paralogues and is associated with 15 phenotypes. Biased expression in cortex adult (RPKM 62.), frontal lobe adult (RPKM 44.4) and 8 other tissues.

Summary

Enables Calcium Channel regulator activity and protein kinase C activity. Involved in several processes, including modulation of chemical synaptic transmission; positive regulation of NF-kappaB transcription factor activity; and positive regulation of signal transduction. Acts upstream of or within several processes, including cellular calcium ion homeostasis; cellular response to carbohydrate stimulus; and response to hypoxia. Located in cytoplasm; membrane; and nucleus. Part of spectrin. Is active in calyx of Held and presynaptic cytosol. Is expressed in several structures, including central nervous system; genitourinary system; heart ventricle; retina; and salivary gland. Human ortholog(s) of this gene implicated in dilated cardiomyopathy and lung non-small cell carcinoma. Orthologous to human PRKCB (protein kinase C beta). [provided by Alliance of Genome Resources, Apr 2022]

Prkcb Products(2)

mRNA Protein Name
NM_001316672.1 NP_001303601.1 protein kinase C beta type isoform 2
NM_008855.2 NP_032881.1 protein kinase C beta type isoform 1

Prkcb Protein Structure

C1_cPKC_rpt1

C1_cPKC_rpt1: cd20833 (34 - 91)

C1_cPKC_rpt2

C1_cPKC_rpt2: cd20836 (101 - 154)

C2_PKC_alpha_gamma

C2_PKC_alpha_gamma: cd04026 (158 - 288)

STKc_cPKC_beta

STKc_cPKC_beta: cd05616 (340 - 662)

  • 0
  • 200
  • 400
  • 600
  • 673 a.a.
Protein Preferred Names Protein Names

protein kinase C beta type

protein kinase C beta-II

protein kinase C, beta 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11119 PRKCB Human Pre-designed siRNA Set A / Unkown
HY-RS11120 Prkcb Mouse Pre-designed siRNA Set A / Unkown
HY-RS11121 Prkcb Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prkcb NCBI NCBI:5579