Prkcb - protein kinase C, beta Gene

Also Known as Pkcb; PKC-B; Prkcb1; Prkcb2; PKC-Beta

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18751

About Prkcb

Chromosome 7: 121,887,974-122,233,625 forward strand.GRCm39:CM001000.3

This gene has 8 transcripts (splice variants), 287 orthologues, 9 paralogues and is associated with 15 phenotypes. Biased expression in cortex adult (RPKM 62.), frontal lobe adult (RPKM 44.4) and 8 other tissues.

Summary

Enables Calcium Channel regulator activity and protein kinase C activity. Involved in several processes, including modulation of chemical synaptic transmission; positive regulation of NF-kappaB transcription factor activity; and positive regulation of signal transduction. Acts upstream of or within several processes, including cellular calcium ion homeostasis; cellular response to carbohydrate stimulus; and response to hypoxia. Located in cytoplasm; membrane; and nucleus. Part of spectrin. Is active in calyx of Held and presynaptic cytosol. Is expressed in several structures, including central nervous system; genitourinary system; heart ventricle; retina; and salivary gland. Human ortholog(s) of this gene implicated in dilated cardiomyopathy and lung non-small cell carcinoma. Orthologous to human PRKCB (protein kinase C beta). [provided by Alliance of Genome Resources, Apr 2022]

Prkcb Products (2)

mRNA Protein Name
NM_001316672.1 NP_001303601.1 protein kinase C beta type isoform 2
NM_008855.2 NP_032881.1 protein kinase C beta type isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium channel regulator activity IDA
IDA: Inferred from direct assay
11880265 MGI
enables calcium,diacylglycerol-dependent serine/threonine kinase activity IDA
IDA: Inferred from direct assay
27226533 MGI
enables diacylglycerol-dependent serine/threonine kinase activity IDA
IDA: Inferred from direct assay
12618484 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15188402 MGI
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
23775122 MGI
Biological Process GO Annotation Evidence References Source
involved in B cell activation IMP
IMP: Inferred from mutant phenotype
12118249 MGI
involved in B cell receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
12118249 MGI
acts upstream of or within calcium ion transport IDA
IDA: Inferred from direct assay
11880265 MGI
acts upstream of or within cellular response to carbohydrate stimulus IDA
IDA: Inferred from direct assay
16585392 MGI
acts upstream of or within intracellular calcium ion homeostasis IDA
IDA: Inferred from direct assay
11880265 MGI
involved in negative regulation of D-glucose transmembrane transport IMP
IMP: Inferred from mutant phenotype
10499500 MGI
involved in phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway IDA
IDA: Inferred from direct assay
27226533 MGI
involved in positive regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
11805327 MGI
involved in positive regulation of canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
12118249 MGI
involved in positive regulation of insulin secretion IDA
IDA: Inferred from direct assay
27226533 MGI
involved in positive regulation of vascular endothelial growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
11805327 MGI
involved in presynaptic modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
21658591 MGI
involved in presynaptic modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
21658591 MGI
acts upstream of or within protein phosphorylation IDA
IDA: Inferred from direct assay
12618484 MGI
involved in regulation of synaptic vesicle exocytosis IDA
IDA: Inferred from direct assay
21658591 MGI
involved in regulation of synaptic vesicle exocytosis IMP
IMP: Inferred from mutant phenotype
21658591 MGI
Cellular Component GO Annotation Evidence References Source
is active in calyx of Held IDA
IDA: Inferred from direct assay
21658591 MGI
is active in calyx of Held IMP
IMP: Inferred from mutant phenotype
21658591 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
12826667 MGI
located in nucleus IDA
IDA: Inferred from direct assay
14613966 MGI
is active in plasma membrane IDA
IDA: Inferred from direct assay
27226533 MGI
is active in presynaptic cytosol IDA
IDA: Inferred from direct assay
21658591 MGI
part of spectrin IDA
IDA: Inferred from direct assay
10534118 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Prkcb Protein Structure

C1_cPKC_rpt1

C1_cPKC_rpt1: cd20833 (34 - 91)

C1_cPKC_rpt2

C1_cPKC_rpt2: cd20836 (101 - 154)

C2_PKC_alpha_gamma

C2_PKC_alpha_gamma: cd04026 (158 - 288)

STKc_cPKC_beta

STKc_cPKC_beta: cd05616 (340 - 662)

  • 0
  • 200
  • 400
  • 600
  • 673 a.a.
Protein Preferred Names Protein Names

protein kinase C beta type

  • protein kinase C beta-II

  • protein kinase C, beta 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11119 PRKCB Human Pre-designed siRNA Set A / Unkown
HY-RS11120 Prkcb Mouse Pre-designed siRNA Set A / Unkown
HY-RS11121 Prkcb Rat Pre-designed siRNA Set A / Unkown
HY-174542 Human PRKCB mRNA / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prkcb NCBI NCBI:5579