Plau - plasminogen activator, urokinase Gene

Also Known as uPA; u-PA

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18792

Summary

Predicted to enable serine-type endopeptidase activity. Acts upstream of or within several processes, including fibrinolysis; response to hypoxia; and smooth muscle cell migration. Predicted to be located in cell surface and membrane. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; integumental system; and trophectoderm. Used to study Alzheimer's disease; fatty liver disease; and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease (multiple); Quebec platelet disorder; end stage renal disease; lung disease (multiple); and mitral valve prolapse. Orthologous to human PLAU (plasminogen activator, urokinase). [provided by Alliance of Genome Resources, Apr 2022]

Plau Products (1)

mRNA Protein Name
NM_008873.3 NP_032899.1 urokinase-type plasminogen activator precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25168896 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within fibrinolysis IMP
IMP: Inferred from mutant phenotype
9733098 MGI
acts upstream of or within regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
17893885 MGI
acts upstream of or within response to hypoxia IMP
IMP: Inferred from mutant phenotype
17382917 MGI
acts upstream of or within smooth muscle cell migration IMP
IMP: Inferred from mutant phenotype
17382917 MGI
Cellular Component GO Annotation Evidence References Source
part of serine-type endopeptidase complex IPI
IPI: Inferred from physical interaction
20133942 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

urokinase-type plasminogen activator

  • U-plasminogen activator

Recombinant Plau Proteins

Cat. No. Product Name Accession Purity
HY-P78017 PLAU/uPA Protein, Mouse (HEK293, C-His-Avi) P06869 (G21-F433) ≥ 95%, as determined by reducing SDS-PAGE or Bis-Tris PAGE.
HY-P78018 PLAU/uPA Protein, Mouse (Biotinylated, HEK293, His-Avi) P06869 (G21-F433) ≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10647 PLAU Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17095 Plau Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-183939 L1-CIDE-BRM1-13 / Unkown
HY-RS23539 Plau Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Plau NCBI NCBI:5328