Pld3 - phospholipase D family, member 3 Gene

Also Known as Sam-9

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18807

Summary

Enables single-stranded DNA 5'-3' exodeoxyribonuclease activity. Involved in regulation of cytokine production involved in inflammatory response. Located in late endosome membrane and lysosomal membrane. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in spinocerebellar ataxia 46. Orthologous to human PLD3 (Phospholipase D family member 3). [provided by Alliance of Genome Resources, Apr 2022]

Pld3 Products (2)

mRNA Protein Name
NM_001317355.1 NP_001304284.1 5'-3' exonuclease PLD3
NM_011116.2 NP_035246.1 5'-3' exonuclease PLD3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
NOT enables phospholipase D activity IDA
IDA: Inferred from direct assay
9813063 MGI
enables single-stranded DNA 5'-3' DNA exonuclease activity IDA
IDA: Inferred from direct assay
30111894 MGI
Biological Process GO Annotation Evidence References Source
involved in regulation of cytokine production involved in inflammatory response IMP
IMP: Inferred from mutant phenotype
22102906 MGI
Cellular Component GO Annotation Evidence References Source
located in late endosome membrane IDA
IDA: Inferred from direct assay
28128235 MGI
located in lysosomal membrane IDA
IDA: Inferred from direct assay
28128235 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

5'-3' exonuclease PLD3

  • PLD 3

  • choline phosphatase 3

  • phosphatidylcholine-hydrolyzing phospholipase D3

  • phospholipase D3

  • schwannoma-associated protein 9

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10672 PLD3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20795 Pld3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27309 Pld3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pld3 NCBI NCBI:23646