Septin4 - septin 4 Gene

Also Known as Bh5; ARTS; Sept4; Pnutl2; Gm11492; hCDCREL-2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18952

Summary

Predicted to enable several functions, including GTP binding activity; GTPase activity; and magnesium ion binding activity. Involved in flagellated sperm motility; neuron migration; and spermatid differentiation. Acts upstream of or within brain development; sperm capacitation; and sperm mitochondrion organization. Located in several cellular components, including dendrite; perikaryon; and sperm annulus. Part of septin complex. Is expressed in several structures, including central nervous system; olfactory epithelium; and retina. Orthologous to human SEPTIN4 (septin 4). [provided by Alliance of Genome Resources, Apr 2022]

Septin4 Products (10)

mRNA Protein Name
NM_001284392.2 NP_001271321.1 septin-4 isoform 2
NM_001284394.2 NP_001271323.1 septin-4 isoform 3
NM_001284398.2 NP_001271327.1 septin-4 isoform 4
NM_001361936.2 NP_001348865.1 septin-4 isoform 5
NM_001368775.2 NP_001355704.1 septin-4 isoform 6
NM_001368776.2 NP_001355705.1 septin-4 isoform 7
NM_001368777.2 NP_001355706.1 septin-4 isoform 8
NM_001368778.2 NP_001355707.1 septin-4 isoform 9
NM_001368779.2 NP_001355708.1 septin-4 isoform 10
NM_011129.3 NP_035259.1 septin-4 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17296554 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within brain development IMP
IMP: Inferred from mutant phenotype
16314519 MGI
involved in flagellated sperm motility IMP
IMP: Inferred from mutant phenotype
15737930 MGI
involved in hematopoietic stem cell homeostasis IMP
IMP: Inferred from mutant phenotype
20952537 MGI
involved in negative regulation of stem cell proliferation IMP
IMP: Inferred from mutant phenotype
30389919 MGI
involved in neuron migration IMP
IMP: Inferred from mutant phenotype
20181826 MGI
acts upstream of or within sperm capacitation IMP
IMP: Inferred from mutant phenotype
15737931 MGI
acts upstream of or within sperm mitochondrion organization IMP
IMP: Inferred from mutant phenotype
15737931 MGI
acts upstream of or within spermatid development IMP
IMP: Inferred from mutant phenotype
15737931 MGI
involved in spermatid differentiation IMP
IMP: Inferred from mutant phenotype
15737931 MGI
involved in tissue morphogenesis IMP
IMP: Inferred from mutant phenotype
30389919 MGI
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
20181826 MGI
located in axon terminus IDA
IDA: Inferred from direct assay
17296554 MGI
located in cell projection IDA
IDA: Inferred from direct assay
11064363 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
20181826 MGI
located in dendrite IDA
IDA: Inferred from direct assay
20181826 MGI
located in motile cilium IMP
IMP: Inferred from mutant phenotype
15737931 MGI
located in perikaryon IDA
IDA: Inferred from direct assay
20181826 MGI
part of septin complex IDA
IDA: Inferred from direct assay
18809578 MGI
located in sperm annulus IDA
IDA: Inferred from direct assay
15737930 MGI
located in sperm flagellum IDA
IDA: Inferred from direct assay
23976951 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

septin-4

  • CE5B3 beta

  • M-Septin

  • bradeion beta

  • brain protein H5

  • cell division control-related protein 2

  • cell division control-related protein 2b

  • peanut-like 2 homolog

  • peanut-like protein 2

  • septin H5

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12683 SEPTIN4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21254 Septin4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27771 Septin4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Septin4 NCBI NCBI:5414