Ptger4 - prostaglandin E receptor 4 (subtype EP4) Gene

Also Known as EP4; Ptgerep4

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19219

Summary

Predicted to enable prostaglandin E receptor activity. Involved in several processes, including T-helper cell differentiation; regulation of cytokine production; and regulation of stress fiber assembly. Acts upstream of or within several processes, including cellular response to mechanical stimulus; regulation of ossification; and response to lipopolysaccharide. Predicted to be located in neuron projection terminus; neuronal cell body; and nuclear membrane. Predicted to be active in plasma membrane. Is expressed in central nervous system; early conceptus; heart valve; retina; and secondary oocyte. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in ankylosing spondylitis; arteriosclerosis; and ulcerative colitis. Orthologous to human PTGER4 (prostaglandin E receptor 4). [provided by Alliance of Genome Resources, Apr 2022]

Ptger4 Products (2)

mRNA Protein Name
NM_001136079.2 NP_001129551.1 prostaglandin E2 receptor EP4 subtype isoform 1
NM_008965.2 NP_032991.1 prostaglandin E2 receptor EP4 subtype isoform 2

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in T-helper cell differentiation IDA
IDA: Inferred from direct assay
19465928 MGI
involved in cellular response to mechanical stimulus IEP
IEP: Inferred from expression pattern
14665434 MGI
acts upstream of or within interleukin-33 production IMP
IMP: Inferred from mutant phenotype
32484881 MGI
involved in negative regulation of cytokine production IMP
IMP: Inferred from mutant phenotype
11602631 MGI
acts upstream of or within negative regulation of inflammatory response IGI
IGI: Inferred from genetic interaction
18270204 MGI
acts upstream of or within negative regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
18270204 MGI
involved in positive regulation of cytokine production IDA
IDA: Inferred from direct assay
19465928 MGI
involved in positive regulation of inflammatory response IDA
IDA: Inferred from direct assay
19465928 MGI
acts upstream of or within regulation of ossification IMP
IMP: Inferred from mutant phenotype
10749873 MGI
involved in regulation of stress fiber assembly IDA
IDA: Inferred from direct assay
14665434 MGI
acts upstream of or within response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
15834430 MGI
acts upstream of or within response to nematode IMP
IMP: Inferred from mutant phenotype
32484881 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

prostaglandin E2 receptor EP4 subtype

  • PGE2 receptor EP4 subtype

  • prostanoid EP4 receptor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11378 PTGER4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18874 Ptger4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25365 Ptger4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ptger4 NCBI NCBI:5734